Preventive Angioplasty in Myocardial Infarction Trial
| ISRCTN | ISRCTN73028481 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN73028481 |
| Protocol serial number | 07/H0703/109 |
| Sponsor | Queen Mary University of London (UK) |
| Funder | Bart's and the London Trust (BLT) Charitable Foundation (UK) |
- Submission date
- 25/08/2009
- Registration date
- 07/10/2009
- Last edited
- 27/09/2013
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr David Wald
Scientific
Scientific
Wolfson Institute of Preventive Medicine
Charterhouse Square
London
EC1M 6BQ
United Kingdom
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | Preventive Angioplasty in Myocardial Infarction Trial: a randomised controlled trial |
| Study acronym | PRAMI |
| Study objectives | A randomised trial among patients with an acute myocardial infarction (AMI) undergoing a therapeutic angioplasty (a procedure to unblock the artery causing the AMI), to determine the value of preventive angioplasty (additional angioplasty to dilate all other narrowed coronary arteries that were not the cause of the AMI but may cause a future infarct) undertaken as an immediate follow-on procedure. |
| Ethics approval(s) | East London and the City Research Ethics Committee approved in December 2007 |
| Health condition(s) or problem(s) studied | Coronary artery disease |
| Intervention | Six hundred patients with AMI will be allocated at random to receive therapeutic angioplasty alone or therapeutic angioplasty plus preventive angioplasty undertaken as an immediate follow-on procedure. Patients will be followed up for an average of 3 years. |
| Intervention type | Other |
| Primary outcome measure(s) |
All outcomes will be recorded during the period of follow up and analysed 1 year after the last patient is recruited: |
| Key secondary outcome measure(s) |
All outcomes will be recorded during the period of follow up and analysed 1 year after the last patient is recruited: |
| Completion date | 14/04/2012 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Other |
| Sex | All |
| Target sample size at registration | 600 |
| Key inclusion criteria | Patients (no age limits, either sex) with acute myocardial infarction undergoing a therapeutic angioplasty to the infarct related artery |
| Key exclusion criteria | 1. Cardiogenic shock 2. Coronary artery bypass graft (CABG) |
| Date of first enrolment | 14/04/2008 |
| Date of final enrolment | 14/04/2012 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
Wolfson Institute of Preventive Medicine
London
EC1M 6BQ
United Kingdom
EC1M 6BQ
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 19/09/2013 | Yes | No | |
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
| Study website | Study website | 11/11/2025 | 11/11/2025 | No | Yes |
