The arcOGEN study: a genome wide association study of osteoarthritis
| ISRCTN | ISRCTN73561469 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN73561469 |
| Protocol serial number | 4628 |
| Sponsor | Newcastle upon Tyne Hospitals NHS Foundation Trust (UK) |
| Funder | Arthritis Research Campaign (ARC) (UK) |
- Submission date
- 23/04/2010
- Registration date
- 27/05/2010
- Last edited
- 22/11/2013
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Musculoskeletal Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof John Loughlin
Scientific
Scientific
The Medical School
Queen Victoria Road
Newcastle
NE1 4LP
United Kingdom
Study information
| Primary study design | Observational |
|---|---|
| Study design | Non-randomised observational trial in primary, secondary and tertiary centres |
| Secondary study design | Multi-centre |
| Study type | Participant information sheet |
| Scientific title | A non-randomised observational trial in participants with primary osteoarthritis who will be used for mapping osteoarthritis susceptibility genes by genome-wide association scan |
| Study acronym | arcOGEN |
| Study objectives | A collection of participants with primary osteoarthritis who will be used for mapping osteoarthritis susceptibility genes by genome-wide association scan and by other genetic approaches. |
| Ethics approval(s) | Oxfordshire Research Ethics Committee (REC) C approved on the 3rd January 2008 (ref: 07/H0606/150) |
| Health condition(s) or problem(s) studied | Topic: Musculoskeletal; Subtopic: Musculoskeletal (all Subtopics); Disease: Musculoskeletal |
| Intervention | There is no intervention in this trial. Recruited participants have a blood sample taken for a DNA test and a questionnaire will be answered. No treatments are given. |
| Intervention type | Other |
| Primary outcome measure(s) |
Questionnaire, completed at time of blood sampling |
| Key secondary outcome measure(s) |
No secondary outcome measures |
| Completion date | 31/12/2010 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 8000 |
| Key inclusion criteria | 1. Primary osteoarthritis ascertained by joint replacement of the hip or the knee 2. Male and female, lower age limit of 40 years |
| Key exclusion criteria | Secondary forms of osteoarthritis or non-osteoarthritic diseases that result in joint replacement surgery |
| Date of first enrolment | 01/03/2008 |
| Date of final enrolment | 31/12/2010 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
The Medical School
Newcastle
NE1 4LP
United Kingdom
NE1 4LP
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/05/2011 | Yes | No | |
| Results article | results | 01/09/2012 | Yes | No | |
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
