A Prospective-Study of the Effects of Prolonged Timolol Therapy on Alpha-Adrenoceptor and Beta-Adrenoceptor and Angiotensin-II Receptor-Mediated Responses in Normal Subjects

ISRCTN	ISRCTN76842657
DOI	https://doi.org/10.1186/ISRCTN76842657
Protocol serial number	N/A
Sponsor	NHS R&D Regional Programme Register - Department of Health (UK)
Funder	NHS Executive Eastern (UK)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Dr A Ferro
Scientific

University of Cambridge
Department of Medicine
Clinical Pharmacology Unit
Cambridge
CB2 2QQ
United Kingdom

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	Not provided at time of registration
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Hypertension
Intervention	Timolol 10 mg twice daily or placebo for 14 days
Intervention type	Other
Primary outcome measure(s)	Not provided at time of registration
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	30/09/1996

Participant type(s)	Patient
Age group	Adult
Sex	Male
Target sample size at registration	6
Key inclusion criteria	Healthy males
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/03/1996
Date of final enrolment	30/09/1996

University of Cambridge

Cambridge
CB2 2QQ
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/03/1997		Yes	No