Clinical benefits of additional resistance-type exercise during an endurance-type exercise intervention in coronary artery disease patients

ISRCTN	ISRCTN81212339
DOI	https://doi.org/10.1186/ISRCTN81212339
Protocol serial number	07.48/cardio07.081
Sponsor	Heart Centre Hasselt vzw (Belgium)
Funder	Heart Centre Hasselt vzw (Belgium)

Submission date: 14/01/2010
Registration date: 09/02/2010
Last edited: 09/02/2010

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Circulatory System

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Dominique Hansen
Scientific

Jessa Hospital
Stadsomvaart 11
Hasselt
3500
Belgium

Study information

Primary study design	Interventional
Study design	Prospective randomised clinical trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title	Clinical benefits of additional resistance-type exercise during an endurance-type exercise intervention in coronary artery disease patients: a randomised controlled trial
Study acronym	STIMCARE
Study objectives	We hypothesise that by adding resistance-type exercise during an endurance-type exercise intervention, significantly greater clinical benefits are achieved in coronary artery disease patients.
Ethics approval(s)	Medical Ethical Committee of Jessa Hospital approved on the 29th January 2007 (ref: 07.48/cardio07.081)
Health condition(s) or problem(s) studied	Coronary artery disease
Intervention	All subjects exercised under close supervision of experienced physiotherapists three days per week for a total duration of six weeks in the cardiac rehabilitation centre of the hospital. Exercise training intensity was determined by baseline VO2 peak assessment: subjects exercised at a heart rate corresponding to 65% of baseline VO2 peak, for 40 minutes each exercise training session (17 minutes cycling, 13 minutes walking, 10 minutes arm cranking). Subjects were randomly (by coin) assigned to an endurance-training group, or combined endurance and strength-training group.
Intervention type	Other
Primary outcome measure(s)	1. Maximal exercise capacity 2. Sub-maximal exercise capacity 3. Muscle strength 4. Blood plasma lipid profile and glycaemic control 5. Habitual activity level These measurements were executed at entry of rehabilitation, and after 7 weeks of rehabilitation.
Key secondary outcome measure(s)	1. Blood endothelial progenitor cell 2. Cytokine content These measurements were executed at entry of rehabilitation, and after 7 weeks of rehabilitation.
Completion date	01/03/2010

Eligibility

Participant type(s)	Patient
Age group	Adult
Sex	All
Target sample size at registration	60
Key inclusion criteria	60 coronary artery disease (CAD) patients (aged between 45 - 80 years, either sex) agreed to participate in this study.
Key exclusion criteria	1. Complicated hospitalisation (renal failure, sepsis) 2. Delayed and/or complicated sternum healing 3. Hypertension (greater than 150 mmHg systolic blood pressure at rest and/or greater than 250 mmHg systolic blood pressure during exercise) 4. Presence of pulmonary and renal co-morbidity 5. Peripheral artery disease 6. Orthopaedic limitations 7. Subjects presenting myocardial ischaemia and/or severe ventricular arrhythmias during baseline exercise testing
Date of first enrolment	01/02/2008
Date of final enrolment	01/03/2010

Locations

Countries of recruitment

Belgium

Study participating centre

Jessa Hospital

Hasselt
3500
Belgium

Results and Publications

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes