Oral chemotherapy versus intravenous chemotherapy in limited or extensive small cell lung cancer

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr - -
Scientific

UKCCCR Register Co-ordinator
MRC Clinical Trials Unit
222 Euston Road
London
NW1 2DA
United Kingdom

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title	Oral chemotherapy versus intravenous chemotherapy in limited or extensive small cell lung cancer: a randomised controlled trial
Study objectives	Not provided at time of registration
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Lung (small cell)
Intervention	1. Oral Regimen: Oral etoposide and cyclophosphamide given over 5 days every 3 weeks. 2. Intravenous Regimen: Intravenous combination of three or more drugs routinely used in the centre with the usual dose reduction. A standard alternative is adriamycin, cyclophosphamide and vincristine (VAC) repeated every 3 weeks.
Intervention type	Other
Primary outcome measure(s)	Not provided at time of registration
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	31/12/2000
Reason abandoned (if study stopped)	Objectives no longer viable

Participant type(s)	Patient
Age group	Not Specified
Sex
Key inclusion criteria	1. Histologically or cytologically proven small cell lung cancer 2. No previous or concurrent malignancy 3. Fit to receive chemotherapy 4. No prior chemotherapy or radiotherapy 5. No biochemical or haematological abnormalities which would preclude chemotherapy
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/01/1995
Date of final enrolment	31/12/2000

UKCCCR Register Co-ordinator

London
NW1 2DA
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Interim results article	interim results	31/08/1996		Yes	No
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes

18/09/2017: internal review.