CHEST - Pilot Study CPAP: Heliox Effects on Stability and Therapeutics

ISRCTN	ISRCTN82423314
DOI	https://doi.org/10.1186/ISRCTN82423314
Protocol serial number	AL001
Sponsor	Imperial College London (UK)
Funder	Gas will be provided by BOC Ltd. Equipment and application fees will be provided by Viasys

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr Parviz Habibi
Scientific

Imperial College London
Norfolk Place
London
W21PG
United Kingdom

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study acronym	CHEST
Study objectives	Heliox + oxygen driven continuous positive airway pressure (CPAP) reduces work of breathing and improves oxygenation and carbon dioxide clearance more than air + oxygen driven CPAP
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Respiratory distress requiring CPAP
Intervention	Heliox + oxygen driven continuous positive airway pressure (CPAP) versus air + oxygen driven CPAP.
Intervention type	Other
Primary outcome measure(s)	Work of breathing
Key secondary outcome measure(s)	Oxygenation, carbon dioxide clearance
Completion date	01/03/2007
Reason abandoned (if study stopped)	Lack of funding

Participant type(s)	Patient
Age group	Child
Upper age limit	1 Year
Sex	All
Target sample size at registration	20
Key inclusion criteria	Children under 1 year of age with respiratory distress requiring CPAP
Key exclusion criteria	Refusing consent, pneumothorax, FiO2 >0.6, imminent intubation, respiratory failure
Date of first enrolment	01/09/2005
Date of final enrolment	01/03/2007

Imperial College London

London
W21PG
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan