A randomised prospective study to evaluate laser peripheral iridotomy with YAG laser against sequential argon-YAG laser in dark irides

ISRCTN	ISRCTN82666926
DOI	https://doi.org/10.1186/ISRCTN82666926
Protocol serial number	N0141184531
Sponsor	Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Funder	Moorfields Eye Hospital NHS Foundation Trust (UK), NHS R&D Support Funding

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Mr Julian DeSilva
Scientific

Moorfields Eye Hospital
162 City Road
London
EC1V 2PD
United Kingdom

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title	A randomised prospective study to evaluate laser peripheral iridotomy with YAG laser against sequential argon-YAG laser in dark irides
Study objectives	To identify the advantages of combined argon-YAG laser iridotomy versus YAG laser alone, in patients of darkly pigmented irides.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Eye Diseases: Pigmentation disorders
Intervention	1. Pure YAG laser 2. Argon-YAG Laser
Intervention type	Procedure/Surgery
Primary outcome measure(s)	Total YAG laser power utilised
Key secondary outcome measure(s)	1. Complications (iris haemorrhage, elevated intraocular pressure, intraocular inflammation, focal corneal opacity) 2. Patency of laser iridotomy after single treatment 3. Cost implications of 2 laser treatments versus need for failed iridotomy requiring a second treatment
Completion date	22/01/2007

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target sample size at registration	30
Key inclusion criteria	1. Require iridotomy in both eyes 2. Informed consent available 3. Can follow up after 3 months 4. Dark irides
Key exclusion criteria	1. Previous failed laser iridotomy 2. History of previous intraocular pathology affecting iris morphology 3. Patients with only 1 functional eye or previous ACG 4. Patients with advanced glaucoma 5. Patients medically unfit for laser treatment
Date of first enrolment	23/08/2006
Date of final enrolment	22/01/2007

Moorfields Eye Hospital

London
EC1V 2PD
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/02/2012		Yes	No
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes

12/10/2017: Publication reference added.