The incidence of ventilator associated pneumonia (VAP) in critically ill patients: comparison of enteral (EN) versus parenteral (PN) nutrition support

ISRCTN	ISRCTN86283280
DOI	https://doi.org/10.1186/ISRCTN86283280
Protocol serial number	N0016141094
Sponsor	Department of Health
Funders	Hammersmith Hospital NHS Trust (UK), NHS R&D Support (UK) - Funding 2004/05

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr Mark Palazzo
Scientific

Intensive Care Unit
Charing Cross Hospital
Fulham Palace Road
Hammersmith
London
W6 8RF
United Kingdom

Phone	+44 (0)20 8846 7018
Email	m.palazzo@imperial.ac.uk

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title	The incidence of ventilator associated pneumonia (VAP) in critically ill patients: comparison of enteral (EN) versus parenteral (PN) nutrition support
Study objectives	Can the incidence of ventilator associated pneumonia be reduced by parenteral nutrition during the acute phase of critical illness?
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Nutrition support
Intervention	Prospective randomised open clinical study taking place at a single centre (ICU_CXH). Patients will be randomised to enteral (EN) versus parenteral (PN) nutrition support.
Intervention type	Other
Primary outcome measure(s)	1. Incidence of ventilator associated pneumonia 2. The number of ventilator free days 3. ICU length of stay 4. ICU mortality
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	29/03/2006

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Key inclusion criteria	Patients expected to require ventilation for 5 or more days
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	29/03/2004
Date of final enrolment	29/03/2006

Charing Cross Hospital

London
W6 8RF
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes

11/07/2016: No publications found, verifying study status with principal investigator.