Prospective, randomised, blind study to compare two flushing media on oocyte collection and fertilisation rates after in vitro fertilisation (IVF)
| ISRCTN | ISRCTN86892369 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN86892369 |
| Protocol serial number | N0059122213 |
| Sponsor | Department of Health (UK) |
| Funder | Sheffield Teaching Hospitals NHS Foundation Trust (UK) |
- Submission date
- 12/09/2003
- Registration date
- 12/09/2003
- Last edited
- 31/10/2019
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Pregnancy and Childbirth
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Karen Martin
Scientific
Scientific
University of Sheffield
OGN & Midwifery
Level 4
Jessop Wing
Sheffield
S10 2SF
United Kingdom
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | Prospective, randomised, blind study to compare two flushing media on oocyte collection and fertilisation rates after in vitro fertilisation (IVF) |
| Study objectives | Prospective, randomised, blind study to compare two flushing media on oocyte collection and fertilisation rates after in vitro fertilisation (IVF). The success rates of human in vitro fertilisation remain disappointingly low, only 25% of couples will take home a baby (HFEA report 1999.) The quality of eggs collected from a woman's ovaries has a significant influence on the implantation potential of any resulting embryos and therefore the chances of a patient becoming pregnant. The aims of this study are: a. To determine whether the medium used to flush ovarian follicles during egg collection in IVF has an impact on oocyte quality, fertilisation rates and subsequent embryo development b. To compare the use of a new complex flushing medium (Sydney IVF Follicle Flushing Buffer, COOK) with our current flushing medium, Hartmann's solution (Baxter). |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Pregnancy and Childbirth: In vitro fertilisation (IVF) |
| Intervention | Compare the use of new complex flushing medium (Sydney IVF Follicle Flushing Buffer, COOK) with our current flushing medium, Hartmann's solution (Baxter). |
| Intervention type | Other |
| Primary outcome measure(s) | Currently unavailable. |
| Key secondary outcome measure(s) | Not provided at time of registration |
| Completion date | 01/09/2003 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Female |
| Key inclusion criteria | Female patients, Assisted Conception Unit. |
| Key exclusion criteria | Does not meet inclusion criteria |
| Date of first enrolment | 01/10/2002 |
| Date of final enrolment | 01/09/2003 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
University of Sheffield
Sheffield
S10 2SF
United Kingdom
S10 2SF
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Abstract results | results presented at the Association of Clinical Embryologists Annual Meeting | 01/01/2009 | 31/10/2019 | No | No |
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
Editorial Notes
31/10/2019: Publication reference added.
13/10/2017: No publications found, study status unverified
