Randomised comparison of nicotine replacement therapy and bupropion in the treatment of tobacco dependence

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Mr John Stapleton
Scientific

Institute Of Psychiatry
Kings College London
Postal Box P075
4 Windsor Walk
London
SE5 8AF
United Kingdom

Phone	+44 (0)20 7848 0450
Email	j.stapleton@iop.kcl.ac.uk

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study acronym	ZORN
Study objectives	To compare effectiveness of the three treatments in routine National Health Service (NHS) care.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Tobacco dependence
Intervention	Group and individual specialist counselling over six weeks, plus NRT, bupropion or both
Intervention type	Drug
Phase	Not Specified
Drug / device / biological / vaccine name(s)	Bupropion
Primary outcome measure(s)	Smoking status at four weeks and 12 months
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	30/06/2007

Participant type(s)	Patient
Age group	Adult
Sex	All
Target sample size at registration	1800
Key inclusion criteria	All smokers eligible to use Nicotine Replacement Therapy (NRT) and bupropion who present for help to stop smoking
Key exclusion criteria	Those with contraindications for NRT or bupropion
Date of first enrolment	01/05/2004
Date of final enrolment	30/06/2007

Institute Of Psychiatry

London
SE5 8AF
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/12/2013		Yes	No