Randomised comparison of nicotine replacement therapy and bupropion in the treatment of tobacco dependence
| ISRCTN | ISRCTN91464711 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN91464711 |
| Secondary identifying numbers | G0200455 |
- Submission date
- 06/08/2003
- Registration date
- 07/08/2003
- Last edited
- 06/05/2014
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Injury, Occupational Diseases, Poisoning
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Mr John Stapleton
Scientific
Scientific
Institute Of Psychiatry
Kings College London
Postal Box P075
4 Windsor Walk
London
SE5 8AF
United Kingdom
| Phone | +44 (0)20 7848 0450 |
|---|---|
| j.stapleton@iop.kcl.ac.uk |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Treatment |
| Scientific title | |
| Study acronym | ZORN |
| Study objectives | To compare effectiveness of the three treatments in routine National Health Service (NHS) care. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Tobacco dependence |
| Intervention | Group and individual specialist counselling over six weeks, plus NRT, bupropion or both |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Bupropion |
| Primary outcome measure | Smoking status at four weeks and 12 months |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/05/2004 |
| Completion date | 30/06/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 1800 |
| Key inclusion criteria | All smokers eligible to use Nicotine Replacement Therapy (NRT) and bupropion who present for help to stop smoking |
| Key exclusion criteria | Those with contraindications for NRT or bupropion |
| Date of first enrolment | 01/05/2004 |
| Date of final enrolment | 30/06/2007 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Institute Of Psychiatry
London
SE5 8AF
United Kingdom
SE5 8AF
United Kingdom
Sponsor information
King's College London (UK)
University/education
University/education
Institute of Psychiatry
De Crespigny Park
London
SE5 8AF
England
United Kingdom
| Website | http://www.iop.kcl.ac.uk/ |
|---|---|
"ROR" |
https://ror.org/0220mzb33 |
Funders
Funder type
Government
Department of Health (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/12/2013 | Yes | No |
