Cold versus hot snare polypectomy in post polypectomy bleeding in small colonic polyps

ISRCTN	ISRCTN91553378
DOI	https://doi.org/10.1186/ISRCTN91553378
Protocol serial number	N/A
Sponsor	Benizelion General Hospital (Greece)
Funder	Benizelion General Hospital (Greece)

Submission date: 26/12/2010
Registration date: 06/05/2011
Last edited: 06/05/2011

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Digestive System

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Gregorios Paspatis
Scientific

Benizelion General Hospital
Gastroenterology Department
Knossou Avenue
Heraklion, Crete
71409
Greece

Email	paspati@admin.teiher.gr

Study information

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title	A prospective, randomised comparison of cold versus hot snare polypectomy in the occurrence of post polypectomy bleeding in small colonic polyps
Study objectives	The aim of our study is to compare cold snare polypectomy (CSP) with hot snare polypectomy (HSP) in the occurrence of postpolypectomy bleeding in small colonic polyps with size 3 - 8 mm.
Ethics approval(s)	Benizelion General Hospital Ethics Committee approved on the 17th December 2010 (ref: 16903)
Health condition(s) or problem(s) studied	Colonic polyps
Intervention	Colonoscopic polypectomy
Intervention type	Other
Primary outcome measure(s)	1. Post polypectomy bleeding 2. All patients were contacted by telephone 12 hours, 2 days and 1 month after procedure and were asked about pain, abdominal tenderness, fever and bleeding 3. In the HSP group, small polyps were removed as a single piece with a standard electrosurgical snare (Sensation Polypectomy Snare 13mm, Microvasive, Boston Scientific, Natick, MA) and monopolar coagulation current, using a 120W OLYMPUS HF-120 generator with a setting of 72W in endocut function 4. In the CSP group, the polyp was removed as a single piece with the same electrosurgical snare. According to expert opinion[3] 1-to 2mm of normal tissue around the small polyp were ensnared in the CSP group. All colonoscopies were performed with wide-angle (170o), high-resolution videocolonoscopes Olympus (CFH180AL, Tokyo, Japan) with a high-definition 1080-line screen - Olympus (OEV191H, Tokyo, Japan) and video processor Olympus (EVIS EXERA II CV-180, Tokyo, Japan). 5. Bowel preparation was accomplished with a 4L electrolyte solution of polyethylene glycol.
Key secondary outcome measure(s)	All patients were contacted by telephone 12 hours, 2 days and 1 month after procedure and were asked about: 1. Pain 2. Abdominal tenderness 3. Fever 4. Bleeding
Completion date	13/10/2010

Eligibility

Participant type(s)	Patient
Age group	Adult
Sex	All
Target sample size at registration	414
Key inclusion criteria	1. All patients founded with small polyps (3 - 8 mm) during colonoscopy 2. Cold snare group (CSP): male/female: 107/101 with age range: 59,4±13,6 3. Hot snare group (HSP): male/female: 125/81 with age range: 61,3±11,0
Key exclusion criteria	1. Cases with bleeding tendency (taking anticoagulant therapy, platelet count of less than 100,000/mm3, or prothrombin time more than 30% above the control 2. Cases with inadequate colonic preparation 3. Patients undergoing anticoagulant or antiplatelet therapy were instructed to discontinue the use of these types of medication at least 7 days before the endoscopic procedure
Date of first enrolment	19/05/2010
Date of final enrolment	13/10/2010

Locations

Countries of recruitment

Greece

Study participating centre

Benizelion General Hospital

Heraklion, Crete
71409
Greece

Results and Publications

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes