Can Repellents Prevent Malaria in Africa?
| ISRCTN | ISRCTN92202008 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN92202008 |
| Protocol serial number | NIMR/HQ/R8a/VolIX/780 |
| Sponsor | Ifakara Health Institute (Tanzania) |
| Funder | Population Services International (PSI) (Tanzania) - Innovations Grant |
- Submission date
- 29/01/2010
- Registration date
- 18/02/2010
- Last edited
- 21/08/2014
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Sarah Moore
Scientific
Scientific
Disease Control and Vector Biology Unit (DCVBU)
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
| sarah.moore@lshtm.ac.uk |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Cluster controlled randomised trial |
| Secondary study design | Randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | Low cost repellents for use in rural Africa: a short-term efficacy, effectiveness and perceived benefit survey in Kilombero, Tanzania |
| Study acronym | CRPMA |
| Study objectives | As Tanzania progresses towards the goals of the Abuja declaration and insecticide-treated bed nets (ITN) coverage becomes almost universal, there is likely to be a selection pressure on malaria mosquitoes to feed outdoors and earlier in the evening when hosts are available. This coupled with changes in lifestyle such as increased access to electricity so people stay awake later means that the relative exposure of the population to infectious mosquito bites is likely to switch to earlier in the evening. A topical insect repellent containing deet can dramatically reduce malaria in South America and Southern Asia where vectors feed early in the evening. The project aims to measure the impact of such a repellent on clinical episodes of malaria in rural Africa. |
| Ethics approval(s) | 1. Ifakara Health Institute Institutional Review Board, 10/11/2008, ref: IHRDC/IRB/No. A46 2. National Institute of Medical Research, Tanzania, 06/03/2009, ref: NIMR/HQ/R8a/VolIX/780 |
| Health condition(s) or problem(s) studied | Malaria |
| Intervention | Long lasting insecticide treated nets (Olyset) + 15% deet repellent Long lasting insecticide treated nets (Olyset) + placebo lotion Total duration of intervention: 44 weeks Total duration of follow-up: 1 month after the trial ends |
| Intervention type | Drug |
| Phase | Not Applicable |
| Drug / device / biological / vaccine name(s) | Deet-containing insect repellent |
| Primary outcome measure(s) |
1. Malaria incidence |
| Key secondary outcome measure(s) |
Malaria prevalence. |
| Completion date | 30/07/2010 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Sex | All |
| Target sample size at registration | 4819 |
| Key inclusion criteria | Household head over 18 years, either sex |
| Key exclusion criteria | Under six months of age |
| Date of first enrolment | 30/08/2009 |
| Date of final enrolment | 30/07/2010 |
Locations
Countries of recruitment
- United Kingdom
- England
- Tanzania
Study participating centre
Disease Control and Vector Biology Unit (DCVBU)
London
WC1E 7HT
United Kingdom
WC1E 7HT
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 16/08/2014 | Yes | No | |
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
