Study of acute ATP supplementation to increase athletic performance
| ISRCTN | ISRCTN96148141 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN96148141 |
| Secondary identifying numbers | AcuteATPBrazil19 |
- Submission date
- 07/07/2021
- Registration date
- 08/07/2021
- Last edited
- 05/01/2022
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nutritional, Metabolic, Endocrine
Plain English summary of protocol
Background and study arms
Acute ATP supplementation has been shown to increase athletic performance, but the minimal effective and optimal doses are currently unknown. This study investigates the effects of three different doses of ATP (400 mg, 200 mg, and 100 mg) on exercise performance.
Who can participate?
Healthy men with at least 1 year of resistance training experience.
What does the study involve?
The study involves four training sessions of four sets of resistance training exercises separated by one week each. Participants are randomly allocated to consume either 100 mg, 200 mg, or 400 mg of ATP or a matching placebo (maltodextrin) 30 minutes before the resistance exercise tests. The total number of repetitions performed for each set is used to analyze performance, and perceived exertion is measured at the end of each session of exercise using a 0 to 10 point scale.
What are the possible benefits and risks of participating?
Any exercise includes the risk of injury. The risk of injury is reduced by appropriate warm-ups, familiarization with the exercise and supervision through trained personnel.
Where is the study run from?
Federal University of Piauí (UFPI) (Brazil)
When is the study starting and how long is it expected to run for?
January 2019 to April 2021
Who is funding the study?
TSI Group, Ltd (USA)
Who is the main contact?
Prof. Dr. Fabrício E. Rossi
fabriciorossi@ufpi.edu.br
Contact information
Scientific
Immunometabolism of Skeletal Muscle and Exercise Research Group
Laboratory of Muscle Performance
Department of Physical Education
Federal University of Piauí (UFPI)
“Ministro Petrônio Portella” Campus
Teresina, Piauí
64049-550
Brazil
| Phone | +55 (0)86 3215 5861 |
|---|---|
| fabriciorossi@ufpi.edu.br |
Study information
| Study design | Double-blind placebo-controlled randomized crossover multiple-dose single-center interventional trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised cross over trial |
| Study setting(s) | Other |
| Study type | Other |
| Participant information sheet | Not available in web format |
| Scientific title | Dose-ranging study of acute ATP supplementation to improve athletic performance |
| Study acronym | AcuteATPPerformance |
| Study objectives | Acute supplementation with 400 mg ATP 30 minutes prior to exercise has been shown to increase athletic performance. However, the optimal and minimal effective dose of ATP to increase exercise performance is currently unknown. Therefore, this study aims to assess the effect of different doses of acute ATP disodium supplementation on exercise performance compared to placebo. |
| Ethics approval(s) | Approved 26/02/2019, the ethics committee of the Federal University of Piaui (Ministro Petrônio Portella Campus, Ininga, Terezina –PI, Brazil; +55 (86) 3237-2332; cep.ufpi@ufpi.br), ref: 3.169.545 |
| Health condition(s) or problem(s) studied | Sports nutrition |
| Intervention | Subjects complete five experimental trials, each separated by 1 week. All trials are performed at the same time (morning) to ensure chronobiological control and are separated by a week. The one rep maximum (1RM) test for half-squats is determined during the first visit. On the following four visits, each subject randomly consumes either 100 mg, 200 mg, or 400 mg of ATP (PEAK ATP®, TSI USA LLC, Missoula, MT, USA) or a matching placebo (maltodextrin). The supplement or placebo is ingested 30 minutes prior to the resistance exercise tests. After that, the participants complete four sets of half-squats until momentary muscular failure with a load corresponding to 80% of the 1RM and 2 minutes of rest between sets. The total number of repetitions performed is recorded for each set and is used to analyze performance and the rate of perceived exertion is measured at the end of each session of exercise using the 0 to 10 point scale. |
| Intervention type | Supplement |
| Primary outcome measure | 1. Number of set 1 repetitions (n) of half-squats until momentary muscular failure with a load corresponding to 80% of the 1RM, recorded by researchers at visits 2, 3, 4 and 5 2. Number of set 2 repetitions (n) of half-squats until momentary muscular failure with a load corresponding to 80% of the 1RM, recorded by researchers at visits 2, 3, 4 and 5 3. Number of set 3 repetitions (n) of half-squats until momentary muscular failure with a load corresponding to 80% of the 1RM. recorded by researchers at visits 2, 3, 4 and 5 4. Number of set 4 repetitions (n) of half-squats until momentary muscular failure with a load corresponding to 80% of the 1RM, recorded by researchers at visits 2, 3, 4 and 5 5. Number of total repetition (n) of half-squats until momentary muscular failure with a load corresponding to 80% of the 1RM, calculated from the sum of set 1, 2, 3, and 4 repetitions at visits 2, 3, 4 and 5 6. Total weight lifted (kg) calculated from the total repetition and the individual 1RM at visits 2, 3, 4 and 5 7. Rate of perceived exertion measured using the visual analogue score (VAS) at visits 2, 3, 4, and 5 |
| Secondary outcome measures | There are no secondary outcome measures |
| Overall study start date | 01/01/2019 |
| Completion date | 30/04/2021 |
Eligibility
| Participant type(s) | Healthy volunteer |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Upper age limit | 35 Years |
| Sex | Male |
| Target number of participants | 20 |
| Total final enrolment | 24 |
| Key inclusion criteria | 1. Age 18–35 years 2. Male 3. Healthy and free of disease (as reported by the health screening questionnaire) 4. Physically active with at least 1 year of resistance training experience at a frequency of 3 days per week and 60 minutes per day and a relative 1RM of 1.5 to 2.0 kg/body weight |
| Key exclusion criteria | 1. Any individual diagnosed with or being treated for cardiac, respiratory, circulatory, musculoskeletal, metabolic, obesity (defined as body mass index >30 kg/m² and body fat greater than 30%), immune, autoimmune, psychiatric, hematological, neurological, or endocrinological disorder or disease were not allowed to participate in the current study. 2. Not used any dietary supplements for at least 6 months before the study 3. Not use any other ergogenic substances or supplements during the study 4. No change in their regular diet and exercise patterns 5. No caffeine consumption 12 hours before each experimental test. |
| Date of first enrolment | 01/03/2019 |
| Date of final enrolment | 28/02/2021 |
Locations
Countries of recruitment
- Brazil
Study participating centre
Laboratory of Muscle Performance
Department of Physical Education
UFPI Campus Universitário Ministro Petrônio Portella
Teresina, Piauí
64049-550
Brazil
Sponsor information
Industry
135 W Main St Suite B
Missoula
59802
United States of America
| Phone | +1 (0)877 549 9123 |
|---|---|
| customersupport@us.tsigroupltd.com | |
| Website | https://tsigroupltd.com/ |
Funders
Funder type
Industry
No information available
Results and Publications
| Intention to publish date | 01/10/2021 |
|---|---|
| Individual participant data (IPD) Intention to share | Yes |
| IPD sharing plan summary | Available on request |
| Publication and dissemination plan | Planned publication in a peer-reviewed scientific journal. |
| IPD sharing plan | The datasets generated during and/or analysed during the current study are/will be available upon request from Prof. Dr. Fabrício E. Rossi (fabriciorossi@ufpi.edu.br). Based on the inquiry, the purpose for the inquiry and the intended use, Prof. Rossi will decide what to share at that point. |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | 08/12/2021 | 05/01/2022 | Yes | No |
Editorial Notes
05/01/2022: Publication reference added.
08/07/2021: Trial's existence confirmed by the ethics committee of the Federal University of Piaui.
