Clinical and molecular mechanisms of periodontal wound healing following surgical treatment of localised aggressive periodontitis
| ISRCTN | ISRCTN98564858 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN98564858 |
| Protocol serial number | N0263156056 |
| Sponsor | Department of Health |
| Funders | UCL Hospitals NHS Foundation Trust (UK), NHS R&D Support Funding |
- Submission date
- 30/09/2005
- Registration date
- 30/09/2005
- Last edited
- 13/03/2014
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Oral Health
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr GS Griffiths
Scientific
Scientific
Periodontology
Periodontology Department
Eastman Dental Institute
256 Gray`s Inn Road
London
WC1X 8LD
United Kingdom
| Phone | +44 (0)20 7 915 1074 |
|---|
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | To explore the clinical and molecular outcome of two surgical treatments (regeneration and repair) for the management of intrabony defects will be compared in patients with aggressive periodontitis. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Periodontitis |
| Intervention | 1. Group A: regeneration treatment 2. Group B: repair treatment |
| Intervention type | Other |
| Primary outcome measure(s) |
The main clinical outcome variables will be Lifetime Cumulative Attachment Loss (LCAL) and level of bone loss. The main laboratory outcome variables will be change in level of specific growth factors (Platelet-Derived Growth Factor [PDGF], Vascular Endothelial Growth Factor [VEGF], Transforming Growth Factor beta [TGFb]), Bone Morphogenetic Protein [BMP] and osteoprotegerin. |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 01/07/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | All |
| Target sample size at registration | 30 |
| Key inclusion criteria | Not provided at time of registration |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 12/01/2005 |
| Date of final enrolment | 01/07/2007 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
Periodontology
London
WC1X 8LD
United Kingdom
WC1X 8LD
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
