Can rehabilitation delivered immediately on hospitalisation for an acute exacerbation of chronic respiratory disease improve long term health outcomes?
| ISRCTN | ISRCTN05557928 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN05557928 |
| Secondary identifying numbers | N/A |
- Submission date
- 07/08/2009
- Registration date
- 02/10/2009
- Last edited
- 10/07/2014
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Respiratory
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English Summary
Not provided at time of registration
Contact information
Mrs Pamela de Chazal
Scientific
Scientific
Department of Pulmonary Rehabilitation
Glenfield Hospital
Leicester
LE3 9QP
United Kingdom
| Phone | +44 (0)116 250 2758 |
|---|---|
| pam.dechazal@uhl-tr.nhs.uk |
Study information
| Study design | Prospective parallel group randomised single blind controlled clinical trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Scientific title | Can rehabilitation delivered immediately on hospitalisation for an acute exacerbation of chronic respiratory disease improve long term health outcomes? A randomised controlled trial |
| Study acronym | The REACH trial |
| Study hypothesis | The hypothesis is that an early and proactive rehabilitation strategy which is delivered immediately on hospitalisation for an acute exacerbation of chronic respiratory disease will prevent the decline in physical function associated with the exacerbation, improve clinical outcomes and reduce the risk of subsequent hospitalisation. |
| Ethics approval(s) | Not provided at time of registration |
| Condition | Chronic respiratory disease |
| Intervention | Treatment for patients in the intervention group will start within 48 hours of admission for an acute exacerbation of chronic respiratory disease. It will take the form of a daily, individually prescribed, graduated exercise and strength training programme and will continue until discharge. After discharge, patients will continue a home-based customised rehabilitation programme for six weeks. Patients in the control group will receive 'best usual care' from the medical, nursing, physiotherapy and occupational therapy teams. |
| Intervention type | Other |
| Primary outcome measure | Hospital readmission rate at 12 months |
| Secondary outcome measures | 1. Exercise capacity, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 2. Health status, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 3. Psychological wellbeing, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 4. Muscle strength and thickness, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 5. Biomarkers, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 6. Spirometry, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 7. Length of stay, measured at discharge home 8. Nutritional status, measured at 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 9. Muscle structure changes, measured at 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 10. Focus groups for psychological analysis, measured at 12 months after discharge 11. Healthcare utilisation, measured at 12 months after discharge |
| Overall study start date | 01/01/2010 |
| Overall study end date | 30/09/2013 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 484 |
| Participant inclusion criteria | 1. Patients aged 40 and over of either sex who are admitted to hospital with an acute exacerbation of chronic respiratory disease 2. Ability to give informed consent |
| Participant exclusion criteria | 1. Musculoskeletal or neuromuscular conditions that significantly contribute to exercise limitation 2. Psychiatric or neurological conditions that render the patient unable to comply with the rehabilitation programme 3. Not living independently at the time of admission 4. Admission for an acute myocardial infarction 5. Terminal disease with an estimated survival time of less than three months 6. Four or more hospitalisations for acute exacerbations of chronic respiratory disease in the preceding 12 month period |
| Recruitment start date | 01/01/2010 |
| Recruitment end date | 30/09/2013 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Department of Pulmonary Rehabilitation
Leicester
LE3 9QP
United Kingdom
LE3 9QP
United Kingdom
Sponsor information
University Hospitals of Leicester NHS Trust (UK)
Hospital/treatment centre
Hospital/treatment centre
Headquarters
Gwendolen House
Gwendolen Road
Leicester
LE5 4QF
England
United Kingdom
| Phone | +44 (0)116 287 1471 |
|---|---|
| carolyn.maloney@uhl-tr.nhs.uk | |
| Website | http://www.uhl-tr.nhs.uk/ |
"ROR" |
https://ror.org/02fha3693 |
Funders
Funder type
Government
National Institute of Health Research (NIHR) (UK) - Collaboration for Leadership in Applied Health Research and Care - Leicestershire, Northamptonshire and Rutland (CLAHRC LNR)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 08/07/2014 | Yes | No |
