Indoor air quality and health – the K-HEALTHinAIR project
| ISRCTN | ISRCTN10927320 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN10927320 |
| Secondary identifying numbers | 101057693 |
- Submission date
- 05/09/2023
- Registration date
- 15/09/2023
- Last edited
- 26/09/2023
- Recruitment status
- No longer recruiting
- Overall study status
- Ongoing
- Condition category
- Respiratory
Plain English Summary
Background and study aims
The negative impact of outdoor air pollution and indoor air quality on health is well-accepted. However, the current knowledge on the health effects of impaired indoor air quality shows numerous gaps (e.g. previous studies cover limited parameters, limited scenarios or are limited in time). Therefore the Knowledge for improving indoor AIR quality and HEALTH (K-HEALTHinAIR) project aims to address these gaps by studying determinants of the effect of indoor air quality on health covering multiple parameters in nine relevant scenarios in six European countries with a project duration of 3 years.
The overall K-HEALTHinAIR project objectives are:
1. Identifying the determinants of indoor air quality and health, and the association between indoor air quality and health, by monitoring indoor air quality and performing big data analyses
2. Confirming the identified determinants and search for their sources by monitoring indoor air quality, performing big data analysis and using supporting studies
3. Testing preventive interventions using continued monitoring of indoor air quality and using reference spaces and theoretical analysis to evaluate interventions.
This registration is for the K-HEALTHinAIR Rotterdam pilot study. The primary objective of the Rotterdam pilot is to study the determinants of indoor air quality and its associations with health and well-being among older adults.
Who can participate?
Older adults (aged 60+ years) living at home. The participants will be recruited in Erasmus Medical Centre (EMC) outpatient clinics (e.g. department of geriatrics, internal medicine, and pulmonary medicine) and in collaboration with senior housing cooperations.
What does the study involve?
Using self-report questionnaires older adults will report on their (general) health and wellbeing and indoor air quality related behavior at the start of the study and at 6 and 12 months of follow-up. A two-page questionnaire on health symptoms related to indoor air quality is completed every 2 months.
What are the possible benefits and risks of participating?
This is a non-invasive study and there are low risks associated with participation. The study involves non-invasive measurements that do not affect the physical and/or psychological integrity of the participants. Participants can withdraw from participation at any time during the study without having to explain why to the research team.
Where is the study run from?
Erasmus Medical Center (Netherlands)
When is the study starting and how long is it expected to run for?
September 2022 to September 2026
Who is funding the study?
European Union - the European Health and Digital Executive Agency (HADEA) as part of HORIZON HEALTH 2021
Who is the main contact?
The main contact of the overall K-HEALTHinAIR project is josdom@cartif.es
The two contacts for the K-HEALTHinAIR Rotterdam pilot study are Amy van Grieken (a.vangrieken@erasmusmc.nl) and Dr Suzanne van den Toren (s.vandentoren@erasmusmc.nl)
Contact information
Principal Investigator
Dr. Molewaterplein 40
Rotterdam
3000CA
Netherlands
 ORCID ID |
0000-0001-6767-9159 |
|---|---|
| Phone | +31 (0)10 704 0 704 |
| a.vangrieken@erasmusmc.nl |
Scientific
Dr. Molewaterplein
Rotterdam
3000CA
Netherlands
| ORCID ID |
0000-0002-0452-9812 |
|---|---|
| Phone | +31 (0)10 704 0 704 |
| s.vandentoren@erasmusmc.nl |
Study information
| Study design | The Rotterdam pilot study uses mixed methods in a small size prospective cohort study, namely self-report questionnaires, a non-intrusive household indoor air quality monitoring device and an observational checklist. |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cohort study |
| Study setting(s) | Built environment/local authority, Community, Home, Hospital |
| Study type | Prevention, Quality of life |
| Participant information sheet | Not available in web format, please use contact details to request participant information sheet |
| Scientific title | Knowledge for improving indoor air quality and health - Rotterdam study |
| Study acronym | K-HEALTHinAIR-Rotterdam |
| Study hypothesis | The primary objective of the K-HEALTHinAIR Rotterdam pilot is to study the determinants of indoor air quality and its associations with health and well-being among older adults. The Rotterdam study is part of the larger K-HEALTHinAIR project funded by grant nr. 101057693. The information below all refers to the Rotterdam pilot study as part of the larger K-HEALTHinAIR project. |
| Ethics approval(s) |
Approved 17/05/2023, Non-WMO Review Committee (Niet WMO Toetsingscommissie) (Dr. Molewaterplein 40, Rotterdam, 3000CA, Netherlands; +31 (0)107033625; metc@erasmusmc.nl), ref: MEC-2023-0293 |
| Condition | General health and well-being in older adults (aged 60+ years) and older adults with pulmonary complaints |
| Intervention | Observational methodology and assessments: 1. Indoor air quality (e.g. particle matter, volatile organic compounds) continuously monitored with air quality sensors 2. Health and well-being (e.g. health complaints, mental health, quality of life, falls) assessed by self-report questionnaire 3. Indoor environment (e.g. cooking type, windows present etc) assessed by observational checklist 4. Indoor air quality related behavior (e.g. opening windows) assessed by self-report questionnaire For the first year, the observations are as follows: Month 0: installation of MICA device, administering of observational checklist and larger questionnaire Month 2: diary questions, 5 days in a row Month 4: diary questions, 5 days in a row Month 6: larger questionnaire Month 8: diary questions, 5 days in a row Month 10: diary questions, 5 days in a row Month 12: larger questionnaire |
| Intervention type | Mixed |
| Primary outcome measure | 1. Quality of life measured using EQ-5D-5L at baseline, 6-month and 12-month follow-up. 2. Mental health measured using PHQ-9 at baseline, 6-month and 12-month follow-up. 3. Indoor air quality (IAQ)-related health symptoms measured using a diary at months 2, 4, 8 and 10 After the 12-month follow-up, the researchers will assess which measurements will be administered and at what frequency for years 2 and 3 of the study. They will update the registration once they have this information. |
| Secondary outcome measures | 1. Indoor air quality measured with MICA devices that measure IAQ continuously for 36 months 2. Indoor air quality related behavior (e.g. opening windows) assessed using a questionnaire every 6 months 3. Measured using International Consortium for Health Outcomes Measurement (ICHOM) adult and older set (combination) at baseline, 6-month and 12-month follow-up: 3.1. Medication and care use 3.2. Falls 3.3. Lifestyle 4. Living situation (perceived IAQ and outdoor air quality [OAQ], window opening, time spent in scenario) measured at baseline, 6-month and 12-month follow-up 5. Time spent at home measured using a diary at months 2, 4, 8 and 10 After the 12-month follow-up, the researchers will assess which measurements will be administered and at what frequency for years 2 and 3 of the study. They will update the registration once they have this information. |
| Overall study start date | 01/09/2022 |
| Overall study end date | 01/09/2026 |
Eligibility
| Participant type(s) | Healthy volunteer |
|---|---|
| Age group | Senior |
| Lower age limit | 60 Years |
| Upper age limit | 110 Years |
| Sex | Both |
| Target number of participants | 110 |
| Participant inclusion criteria | 1. 60+ years old 2. Cognitively capable of providing informed consent 3. Understand the Dutch language |
| Participant exclusion criteria | 1. Not able to comprehend the information provided in Dutch 2. Unable or unwilling to give informed consent 3. Unable to cognitively evaluate the risks and benefits of participation |
| Recruitment start date | 20/09/2023 |
| Recruitment end date | 20/03/2024 |
Locations
Countries of recruitment
- Netherlands
Study participating centre
Rotterdam
3000CA
Netherlands
Sponsor information
Research organisation
47151 Boecillo
Valladolid
Av. Francisco Vallés, 4
Spain
| Phone | +34 (0)983 54 65 04 |
|---|---|
| josdom@cartif.es | |
| Website | http://www.cartif.com/en/ |
"ROR" |
https://ror.org/036krsg33 |
Hospital/treatment centre
Dr. Molewaterplein 40
Rotterdam
3000CA
Netherlands
| Phone | +31 (0)10 704 0 704 |
|---|---|
| secretariaat.mgz@erasmusmc.nl | |
| Website | http://www.erasmusmc.nl/ |
|
"ROR" |
https://ror.org/018906e22 |
Funders
Funder type
Other
Government organisation / National government
- Alternative name(s)
- Health and Digital Executive Agency, HaDEA
Results and Publications
| Intention to publish date | 01/09/2027 |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Data sharing statement to be made available at a later date |
| Publication and dissemination plan | Planned publication in a high-impact peer-reviewed journal |
| IPD sharing plan | The data-sharing plans for the current study are unknown and will be made available at a later date. |
Editorial Notes
26/09/2023: Internal review.
07/09/2023: Study's existence confirmed by the Non-WMO Review Committee.
