Understanding the role of community pharmacy in the support of people with long COVID

ISRCTN ISRCTN12036374
DOI https://doi.org/10.1186/ISRCTN12036374
Secondary identifying numbers NIHR205384
Submission date
14/11/2024
Registration date
02/06/2025
Last edited
02/06/2025
Recruitment status
No longer recruiting
Overall study status
Ongoing
Condition category
Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year

Plain English summary of protocol

Background and study aims:
In the spring of 2020, it became clear that some people who had a COVID-19 infection continued to suffer from persistent or cyclical symptoms including (but not limited to) chest pain, palpitations, shortness of breath, muscle and joint aches and pains, headaches, cognitive impairment, neuropathy, paraesthesia (pins and needles), and fatigue. Various terms and definitions have been used to describe persistent symptoms following COVID-19 infection. ‘Post COVID-19 syndrome’ is an umbrella term for a complex, multisystem illness following an acute COVID-19 infection. The term ‘long COVID’ has been adopted by patient groups as people came together to share their experiences. The World Health Organisation (WHO), National Institute for Health and Care Excellence (NICE) and SNOMED International have all adopted the term ‘post COVID-19 condition’ for classification. The patient-preferred term ‘long COVID’ is used in this application and is intended to capture people with ongoing symptomatic COVID-19 (4-12 weeks after infection) or post-acute COVID-19 (12+ weeks), as defined by NICE.
More than two million people in the UK are currently living with long COVID. The Office for National Statistics (ONS) data indicates that fatigue is the most common symptom (reported by 71% of those with self-reported long COVID), difficulty concentrating (52%), shortness of breath (48%, and muscle ache (47%). People at higher risk of long COVID include females, people aged 35-69 years, those working in social care, people in more deprived areas, and people with another health condition or disability.
To date, the NHS response to long COVID has achieved mixed success. There have been barriers to accessing acceptable and responsive services. In December 2020, specific funding was announced to establish specialist clinics in England to support the management of people with long COVID, however, delivery of these clinics has since proved challenging to sustain due to high demand. The devolved nations have been slow to establish specialist services for people with long COVID; no services are offered in Wales or Scotland. People with long COVID commonly access support groups, particularly online, to share experiences and inform self-management strategies; engagement with these groups is often driven by a perceived lack of understanding and empathy from others, including healthcare professionals.
Community pharmacy is a key strand of primary care and could provide convenient and accessible support for people with Long Covid. Community pharmacy played a key role in supporting COVID vaccinations and supporting people during the pandemic. Pharmacists are increasingly viewed as referral options for people with Long Covid in primary care as part of multi-agency support. The Royal Pharmaceutical Society (RPS) further acknowledge the role pharmacists have in supporting people with Long Covid; the Society recommends pharmacists should be engaged in research on Long Covid and have time protected to keep up to date with the latest evidence and learning resources on long COVID. Pharmacy staff are in an ideal position to advise on the use of over-the-counter medicines and complementary treatment, particularly when people are also being prescribed medications for other illnesses. The proposed research will help us to understand how best to do this.
This study aims to explore the role of community pharmacy in supporting the management of people with long COVID.

Who can participate?
People with long COVID and community pharmacy staff, both aged 18 years and over

What does the study involve?
Phase 1:
Interviews will be conducted with people with long COVID and community pharmacy staff to explore experiences of symptom management and engagement with community pharmacy (past/current/future). This approach will support an in-depth exploration of individual experiences and beliefs about long COVID and its management. Recognising and documenting researcher positionality through reflexivity will be critical in our approach to inquiry, as people with lived experience of long COVID will be involved in some of the data collection.

Phase 2:
A participatory co-design approach involving key stakeholders will inform the development of a novel fit-for-purpose online training resource. The primary aim of the online training will be to improve awareness and understanding of long COVID among community pharmacy staff; and furthermore, to enable community pharmacy staff to provide advice and appropriate signposting. The online training will also introduce learners to long COVID networks to facilitate ongoing learning and promote critical appraisal skills to assess the evidence as it emerges. A certificate of completion will be provided to learners, which can support evidence for revalidation or CPD requirements for example for the General Pharmaceutical Council (GPhC). The participatory co-design will adopt the Centre of Postgraduate Pharmacy Education’s (CPPE) (University of Manchester) rigorous and well-established approach to training development, which is grounded in education theory and seeks to promote inclusion, person-centred care and positive change in practice – as demonstrated elsewhere. Self-efficacy theory and self-determination theory will be used to underpin the development of the training resource and guide behaviour change among learners by establishing understanding and the confidence to apply knowledge.
Two workshops are planned to support the co-design of training. Workshops will take place face-to-face, at Keele University or in a central location convenient for most participants, or online via MS Teams (or equivalent) if participants prefer. A hybrid approach will be made available to accommodate mixed preferences should this be required. Stakeholders will include up to 20 topic experts, people with lived experience of long COVID, primary care practitioners, pharmacy staff, and research team members. Stakeholders will be identified from the pool of qualitative participants (Phase 1), the PPIE group, the Clinical Advisory Group, and existing networks.

What are the possible benefits and risks of participating?:
There are no known risks to participating in this study. All participants will receive a £25 e-voucher for their time and contributions.

Where is the study run from?:
The study is hosted by Keele University School of Medicine, collaborating with Aston University, the University of Kent, and the Centre of Postgraduate Pharmacy Education (UK). All interviews are conducted online, via Microsoft Teams, or by telephone. Face-to-face interviews may be possible, depending on the location.

When is the study starting and how long is it expected to run for?:
April 2024 to August 2025

Who is funding the study?:
National Institute for Health and Care Research (NIHR) (UK), Research for Patient Benefit, reference number NIHR205384

Who is the main contact?:
Dr Tom Kingstone, t.kingstone@keele.ac.uk

Study website

Contact information

Dr Tom Kingstone
Principal Investigator

David Weatherall Building
Keele
ST5 5BG
United Kingdom

Phone +44 (0)1782 738217
Email t.kingstone@keele.ac.uk
Dr Tamsin Fisher
Public, Scientific

David Weatherall Building
Keele
ST5 5BG
United Kingdom

Phone +44 (0)1782 731794
Email t.e.fisher1@keele.ac.uk

Study information

Study designQualitative research study including semi-structured interviews and focus groups
Primary study designObservational
Secondary study designQualitative study
Study setting(s)Pharmacy
Study typeQuality of life, Treatment
Participant information sheet Not available in web format. Please use contact details to request a participant information sheet.
Scientific titleWhat role can community PHARMacy play in the support of people with Long Covid?
Study acronymPHARM-LC
Study objectivesExploring the role of community pharmacy in supporting the management of people with long COVID.
Ethics approval(s)

Approved 01/05/2024, Keele University Research Ethics Committee (David Weatherall Building, Keele, ST5 5BG, United Kingdom; +44 (0) 1782 733937; research.governance@keele.ac.uk), ref: 0791

Health condition(s) or problem(s) studiedLong COVID
InterventionSemi-structured interviews with people with Long COVID and community pharmacy staff.

Participatory co-design approach to develop a fit-for-purpose online training resource for community pharmacy staff to improve awareness and understanding of Long COVID among community pharmacy staff, and enable community pharmacy staff to provide advice and appropriate signposting.
Intervention typeOther
Primary outcome measure1. Patient attitudes towards community pharmacy supporting the management and care of Long COVID
2. Community pharmacy staff attitudes towards supporting patients living with Long COVID
3. Patient and community pharmacy staff attitudes towards training for community pharmacy staff on Long COVID

Collected using interviews with community pharmacy staff and people with long COVID conducted between June 2024 and June 2025. The data will be analysed using a thematic analysis approach.
Secondary outcome measures1. Identification of key topics to include in a training package on Long COVID for community pharmacy staff
2. Identification of design suggestions for a training package on Long COVID for community pharmacy staff

Collected using interviews with community pharmacy staff and people with long COVID conducted between June 2024 and June 2025. The data will be analysed using a thematic analysis approach.
Overall study start date01/04/2024
Completion date31/08/2025

Eligibility

Participant type(s)Patient, Health professional
Age groupAdult
Lower age limit18 Years
SexBoth
Target number of participantsPeople with long COVID n =~20; Community pharmacy staff interviews n =~20; Community pharmacy staff focus groups n =~10
Key inclusion criteriaPatient inclusion criteria:
1. 18 years or older
2. Lived experience of long COVID (symptoms of COVID for 4 weeks or more)
3. Living in the UK

Health professional (interviews and focus groups):
1. Any staff member currently working within a community pharmacy setting
2. 18 years or older
3. Living and working in the UK
Key exclusion criteriaPeople with long COVID:
1. Under 18 years old
2. Living outside of the UK

Community pharmacy staff:
1. Under 18 years old
2. Living and/or working outside of the UK
3. Not currently working in a community pharmacy
4. Not community pharmacy staff (e.g. pharmacist based in GP surgery, or hospital)
Date of first enrolment01/05/2024
Date of final enrolment06/06/2025

Locations

Countries of recruitment

  • England
  • Northern Ireland
  • Scotland
  • United Kingdom
  • Wales

Study participating centres

School of Medicine
David Weatherall Building
Keele
ST5 5BG
United Kingdom
Aston University
The Aston Triangle
Birmingham
B4 7ET
United Kingdom
University of Kent
The Registry
Canterbury
CT2 7NZ
United Kingdom
Centre for Pharmacy Postgraduate Education
Division of Pharmacy and Optometry
Faculty of Biology, Medicine and Health
1st Floor, Stopford Building
The University of Manchester
Oxford Road
Manchester
M13 9PT
United Kingdom

Sponsor information

Keele University
University/education

School of Medicine
David Weatherall Building
Keele
ST5 5BG
England
United Kingdom

Phone +44 (0)1782 733937
Email fmhs.facilities@keele.ac.uk
Website https://www.crn.nihr.ac.uk/
ROR logo "ROR" https://ror.org/00340yn33

Funders

Funder type

Government

Research for Patient Benefit Programme
Government organisation / National government
Alternative name(s)
NIHR Research for Patient Benefit Programme, RfPB
Location
United Kingdom

Results and Publications

Intention to publish date01/07/2026
Individual participant data (IPD) Intention to shareYes
IPD sharing plan summaryAvailable on request
Publication and dissemination plan1. A Final Summary Report of the study will be provided to the REC within 1 year of the end of the study.
2. An online learning module to be hosted by CPPE and ready for national roll-out
3. Study webpages hosted on collaborating institute websites.
4. Two peer-reviewed academic journal articles to report findings from qualitative interviews, co-design processes and piloting
5. One magazine article (e.g. The Conversation) to distil key findings from the research to lay audiences
6. YouTube video to describe the role of community pharmacies in supporting people with long COVID
7. Plain English summary of research findings
8. Infographics to supplement Plain English summaries
9. Up to five conference abstracts

Key outputs will be made publicly available online. Qualitative datasets generated during this research will be made available on reasonable request.
IPD sharing planThe datasets generated during and/or analysed during the current study may be available upon request from the study PI Dr Tom Kingstone (t.kingstone@keele.ac.uk).

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Protocol article 20/03/2025 Yes No

Editorial Notes

14/11/2024: Study's existence confirmed by the Keele University Research Ethics Committee.