Development of novel magnetic resonance imaging (MRI) techniques for neurological applications
| ISRCTN | ISRCTN13036842 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN13036842 |
| Protocol serial number | 5580 |
| Sponsor | University College London (UCL) (UK) |
| Funder | Multiple Sclerosis Society (UK) |
- Submission date
- 21/05/2010
- Registration date
- 21/05/2010
- Last edited
- 08/08/2016
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nervous System Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Ms Claudia Wheeler-Kingshott
Scientific
Scientific
The Institute of Neurology
Queen Square
London
WC1N 3BG
United Kingdom
| c.wheeler-kingshott@ion.ucl.ac.uk |
Study information
| Primary study design | Observational |
|---|---|
| Study design | Single-centre non-randomised observational diagnosis and screening study |
| Secondary study design | Non randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | Development of novel magnetic resonance imaging (MRI) techniques for neurological applications |
| Study objectives | Quantitative magnetic resonance imaging (MRI) techniques may provide additional information in the understanding of several neurological and psychiatric disorders. The development of some of these techniques is still incomplete and the interpretation of results in pathology is thus limited. Scanning healthy subjects and analysing their data will help in making the scanning techniques suitable for clinical applications. This is an ongoing process of continual testing and optimisation. |
| Ethics approval(s) | MREC, ref: 05/Q0502/101 |
| Health condition(s) or problem(s) studied | Topic: Neurological; Subtopic: Neurological (all Subtopics); Disease: Nervous system disorders |
| Intervention | Routine MRI examinations only provide qualitative images of the brain. Quantitative MRI techniques, such as MR spectroscopy (MRS), magnetisation transfer imaging (MTI), diffusion imaging (DI), perfusion imaging (PI) and relaxometry can be particularly useful in the investigation of the pathological substrate of several diseases. Their usefulness is well documented in the literature; however, their application is somehow limited by technical problems. |
| Intervention type | Other |
| Primary outcome measure(s) |
1. Magnetic resonance imaging (MRI) |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 31/07/2009 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Target sample size at registration | 150 |
| Key inclusion criteria | Not provided at time of registration |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 01/01/2006 |
| Date of final enrolment | 31/07/2009 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
The Institute of Neurology
London
WC1N 3BG
United Kingdom
WC1N 3BG
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
Editorial Notes
09/08/2016: No publications found, verifying study status with principal investigator.
