ISRCTN ISRCTN14425442
DOI https://doi.org/10.1186/ISRCTN14425442
Submission date
21/06/2025
Registration date
23/06/2025
Last edited
23/06/2025
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Other
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year

Plain English summary of protocol

Background and study aims
This study explored the quality of life (QoL) of medical students in Syria, where war and academic stress may impact well-being. We used a validated survey (SF-36) to measure physical and mental health and identified factors like smoking and long commutes that affect QoL.

Who can participate?
Medical students at Aleppo University who attended a workshop in March 2024.

What does the study involve?
Participants completed an online survey about their health, lifestyle, and well-being.

What are the possible benefits and risks of participating?
Benefits: Identifies areas for improving student support. Risks: Minimal (anonymous survey)

Where is the study run from?
Aleppo University (Syria)

When is the study starting and how long is it expected to run for?
March 2024 to November 2024

Who is funding the study?
Investigator initiated and funded

Who is the main contact?
Mawadda Chukr (mawadaug1@gmail.com)

Contact information

Miss Mawadda Chukr
Public, Scientific, Principal Investigator

Aleppo University School of Medicine
Aleppo
-
Syria

ORCiD logoORCID ID 0009-0005-4508-9015
Phone +963 981114394
Email mawadaug1@gmail.com

Study information

Study designSingle-center cross-sectional observational study
Primary study designObservational
Secondary study designCross sectional study
Study setting(s)University/medical school/dental school
Study typeQuality of life
Participant information sheet No participant information sheet available
Scientific titleMultivariable analysis of health-related quality of life (HRQoL) factors using the SF-36 questionnaire among medical students at Aleppo university: a cross-sectional study
Study acronymSyria-QoL
Study objectivesThe Arabic version of the SF-36 questionnaire is a reliable tool for measuring HRQoL among Syrian medical students.

Factors such as smoking, chronic diseases, and prolonged transportation time negatively impact HRQoL, while religious beliefs and lower BMI are associated with better HRQoL
Ethics approval(s)

Approved 10/08/2024, Research Ethics Committee of Aleppo University (Faculty of Medicine, Aleppo University, Aleppo, -, Syria; -; cmoffice@alepuniv.edu.sy), ref: 2403

Health condition(s) or problem(s) studiedHealth-Related Quality of Life (HRQoL) in medical students
InterventionThis is a single-center, cross-sectional observational study conducted among medical students at Aleppo University. Participants are enrolled during a Continuing Medical Education (CME) workshop in March 2024.

Enrollment:
Eligible students receive an electronic survey via Telegram and email.
Informed consent is obtained digitally before participation.

Participation:
Participants complete a one-time, self-administered online questionnaire comprising:
Section 1: Sociodemographic data (age, gender, academic year, BMI, smoking status, chronic diseases, etc.).
Section 2: The validated Arabic SF-36 questionnaire to assess HRQoL across 8 domains.
Surveys are mandatory to complete in one sitting; partial responses are excluded.

Duration:
Observation: Single time point (March 2024).

Follow-up: None (cross-sectional design).

Data Handling:
Responses are anonymized and analyzed using Jamovi and SmartPLS for reliability (Cronbach’s α) and multivariable regression.
Intervention typeBehavioural
Primary outcome measureHRQoL scores measured using the Arabic SF-36 questionnaire at a single time point (March 2024). Domains include Physical Component Summary (PCS) and Mental Component Summary (MCS).
Secondary outcome measuresSociodemographic factors (BMI, smoking status, chronic diseases) at a single time point (March 2024)
Overall study start date01/03/2024
Completion date30/11/2024

Eligibility

Participant type(s)Learner/student
Age groupAdult
Lower age limit18 Years
Upper age limit30 Years
SexBoth
Target number of participants300
Total final enrolment181
Key inclusion criteria1. Undergraduate medical students at Aleppo University
2. Attended the CME workshop in March 2024
3. Willing to provide electronic informed consent
Key exclusion criteria1. Incomplete survey responses
2. Non-medical students
Date of first enrolment01/09/2024
Date of final enrolment30/11/2024

Locations

Countries of recruitment

  • Syria

Study participating centre

Aleppo University Faculty of Medicine
Aleppo
-
Syria

Sponsor information

University of Aleppo
University/education

Aleppo University School of Medicine
University Square
Aleppo
-
Syria

Email cmoffice@alepuniv.edu.sy
Website https://alepuniv.edu.sy/
ROR logo "ROR" https://ror.org/03mzvxz96

Funders

Funder type

Other

Investigator initiated and funded

No information available

Results and Publications

Intention to publish date01/09/2025
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot expected to be made available
Publication and dissemination planPlanned publication in a high-impact peer-reviewed journal
IPD sharing planIPD not available for sharing

Editorial Notes

23/06/2025: Trial's existence confirmed by University of Aleppo Faculty of Medicine