Stopping Eculizumab Treatment Safely in atypical Haemolytic Uraemic Syndrome (SETS aHUS)
| ISRCTN | ISRCTN17503205 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN17503205 |
| EudraCT/CTIS number | 2017-003916-37 |
| Secondary identifying numbers | 36901 |
- Submission date
- 04/04/2018
- Registration date
- 20/04/2018
- Last edited
- 13/12/2022
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Urological and Genital Diseases
Plain English Summary
Background and study aims
Atypical hemolytic uremic syndrome (aHUS) is a disease that causes abnormal blood clots to form in small blood vessels in the kidneys. Lifelong treatment with the drug Eculizumab is currently recommended for aHUS due to risk of relapse. Many physicians are now questioning the recommendation for indefinite treatment and feel alternative treatment strategies should be considered. Data from before the availability of Eculizumab suggests that if patients survive the initial episode of aHUS with intact kidney function, less than 50% of patients will subsequently relapse, so over half of patients receiving maintenance Eculizumab treatment could be doing so unnecessarily. Withdrawal of drug would lead to a reduction in the burden of treatment (intravenous Eculizumab injections every 2 weeks and use of prophylactic antibiotics), replacing it with reduced monitoring after a period of intense monitoring. Patients will also avoid potentially fatal complications associated with Eculizumab use (6 of approximately 100 patients treated have suffered severe complications – death, meningococcal or other unexpected, severe infection). There would be cost savings for the NHS of over £10.6 million if 50% of study participants withdraw for the 2 years of the study. Of 10 UK patients identified who have withdrawn from Eculizumab because of patient/physician choice, only 1 patient has required re-initiation of treatment. Relapse may occur after withdrawal of treatment but early re-initiation of treatment should avoid harm to patients. As the number of patients on Eculizumab increases, so does potentially unnecessary treatment, cost to the NHS, and burden of treatment to patients and their families. Therefore, a tested method of safe withdrawal and monitoring will be vital for efficient delivery of this high-cost treatment. The aim of this study is to establish an evidence-based treatment strategy for patients with aHUS that includes safe withdrawal of treatment and the reintroduction of Eculizumab in those patients who relapse.
Who can participate?
Patients aged 2 and over with aHUS who have been on Eculizumab treatment for at least 6 months
What does the study involve?
Patients who consent to withdraw from Eculizumab receive their last dose of Eculizumab at their screening/consent visit. Any patient with a suspected relapse should be reported to the PI at the local site and the aHUS National Service. When a relapse is diagnosed patients restart Eculizumab treatment within 24 hours of presentation. They continue to be followed up for the remainder of their 24-month follow-up period. Patients who are not withdrawing from their Eculizumab treatment continue to receive their standard care and complete questions at the eight specified time points only in the 24-month follow-up period.
What are the possible benefits and risks of participating?
Patients will no longer need to take the Eculizumab treatment and face any potential risks or side effects associated with treatment. Patients are about a thousand times more likely to develop a serious, potentially life threatening infection with meningococcus, a bug that causes meningitis or sepsis. Vaccination, and even antibiotics, do not give complete protection from this. Being in the study will mean that patients will no longer need bi-weekly infusions and will not have to continue taking additional antibiotics to prevent infection. However, it is possible that they may need to restart and continue Eculizumab if a relapse was to occur. The withdrawal of Eculizumab treatment could lead to a relapse of aHUS and relapse-associated complications. When a relapse is diagnosed, the Eculizumab treatment will be restarted within 24 hours of presentation. Patients are told to present to a hospital with their patient card as soon as they begin to feel unwell or the home urine test shows an increase in the level of blood. This is to ensure that the Eculizumab is re-started as soon as possible to reduce the likelihood of kidney damage and associated complications.
Where is the study run from?
1. Freeman Hospital (UK)
2. Royal Devon & Exeter Hospital (UK)
3. Royal Liverpool University Hospital (UK)
4. University College Hospital (UK)
5. Queen Alexandra Hospital (UK)
6. Guy's Hospital (UK)
7. The Royal London Hospital (UK)
8. St James's University (UK)
When is the study starting and how long is it expected to run for?
September 2017 to November 2023
Who is funding the study?
National Institute for Health Research (NIHR) (UK)
Who is the main contact?
Dr Ciara Kennedy
ciara.kennedy1@newcastle.ac.uk
Contact information
Scientific
1-4 Claremont Terrace
Newcastle Clinical Trials Unit
Newcastle
NE2 4AE
United Kingdom
 ORCID ID |
0000-0003-2987-0977 |
|---|---|
| Phone | +44 (0)191 208 2522 |
| ciara.kennedy1@newcastle.ac.uk |
Study information
| Study design | Non-randomised; Both; Design type: Treatment, Drug, Management of Care, Active Monitoring, Health Economic |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Non randomised study |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Participant information sheet | Not available in web format, please use the contact details to request a patient information sheet |
| Scientific title | Multicentre, open label, prospective, single arm study of the safety and impact of eculizumab withdrawal in patients with atypical haemolytic uraemic syndrome |
| Study acronym | SETS aHUS |
| Study hypothesis | The aim of the current trial is to establish an evidence based treatment strategy for patients with atypical Haemolytic Uraemic Syndrome (aHUS) that includes safe withdrawal of treatment and the reintroduction of Eculizumab in those patients who relapse. |
| Ethics approval(s) | North East – Tyne & Wear South Research Ethics Committee, ref: 18/NE/0078 |
| Condition | Atypical hemolytic uremic syndrome |
| Intervention | Patients who consent to withdraw from Eculizumab will receive their last dose of Eculizumab at their screening/consent visit (day -14). Any patient with a suspected relapse should be reported to the PI at the local site and the aHUS National Service. When a relapse is diagnosed patients will restart Eculizumab treatment within 24 hours of presentation. They will continue to be followed up for the remainder of their 24-month follow-up period. Patients who are not withdrawing from their Eculizumab treatment will continue to receive their standard care and complete the health economic questions at the 8 specified time points only in the 24-month follow-up period. |
| Intervention type | Other |
| Primary outcome measure | Number of patients with a Thrombotic Microangiopathy (TMA) related Serious Adverse Event (SAE) defined as any of the following: 1. Irreversible (>3 months) reduction in estimated glomerular filtration rate (eGFR) by ≥20%, not attributable to another cause 2. An episode of AKI attributed to a TMA that requires renal replacement therapy 3. A non-renal manifestation of a TMA that require hospitalisation, cause irreversible organ damage or death Timepoint(s): Only if/when a patient relapses |
| Secondary outcome measures | 1. The effectiveness of a monitoring protocol to detect disease relapse following withdrawal of Eculizumab assessed by: 1.1. The proportion of patients who relapse and restart Eculizumab without the development of a TMA-related SAE (section 3.3) 1.2. The time from the first clinical feature (symptom, positive urinalysis or laboratory result) of a relapse of TMA and the re-introduction of Eculizumab This outcome is ongoing and not measured at any particular timepoint 2. The relapse rate after withdrawal of Eculizumab as determined by the proportion of patients who relapse after Eculizumab is withdrawn. This outcome is ongoing and not measured at any particular time point. A patient could relapse at any point in the 2 years participation period. 3. The proportion of patients, currently on long-term treatment with Eculizumab, who can be maintained off treatment. This outcome is measured at the end of the trial when all relapse data is collected. A patient could relapse at any point in the 2 years participation period. 4. The period from withdrawal to relapse in those patients who restart treatment. This outcome is measured at the end of the trial when all relapse data is collected. 5. The change in estimated GFR as calculated by the CKD-EPI or modified Schwartz equations over the course of the study from baseline (day 0) to end of the study. This outcome is calculated at the end of the trial when all GFR data is collected. GFR data is collected at all 34 visits 6. Important clinical and laboratory indicators of imminent relapse by review of reported symptoms, physical signs, urinalysis and laboratory results prior to the diagnosis of a relapse. This outcome will be assessed at the end of the trial when all relapse data is collected. Those who have relapsed will have all data preceding relapse reviewed to establish a relapse profile 7. The costs and health outcomes (measured in terms of adverse events and quality-adjusted life years [QALYs]) for patients on standard care (not withdrawing from Eculizumab treatment) over the two-year trial duration: 7.1. Healthcare Utilisation Questionnaires for non-withdrawal participants at Day 0, 14, 70,154, 252, 336, 504 and 672 7.2. Adverse Event Assessment at every visit from Day 7 (32 visits) for withdrawal participants 8. QALYs estimated from responses to the EQ-5D-5L, and SF-36 and determinants of QALYs/utilities over the 24-month follow-up period. at Day 0, 14, 70,154, 252, 336, 504 and 672 9. Model-based estimate of the costs and health consequences, with results presented in terms of cost per QALY gained, over the estimated lifetime of patients withdrawing from treatment compared with standard care |
| Overall study start date | 01/09/2017 |
| Overall study end date | 30/11/2023 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Mixed |
| Sex | Both |
| Target number of participants | Planned Sample Size: 50; UK Sample Size: 50 |
| Total final enrolment | 39 |
| Participant inclusion criteria | All patients must fulfil the following criteria in order to be eligible for the trial: 1. Age ≥2+ years of age 2. On Eculizumab treatment for at least 6 months 3. In remission with no evidence of ongoing microangiopathic haemolytic anaemia (MAHA) activity at screening defined by: 3.1. Platelet count > lower limit of normal as determined by local reference range 3.2. Lactate Dehydrogenase (LDH) <x2 upper limit of normal as determined by local lab reference ranges 4. Normal renal function or Chronic Kidney Disease (CKD) stages 1-3 5. Absence of decline of renal function confirmed by review of available assessments of renal function for the preceding 6 months by the Chief Investigator and clinical members of the Trial Management Group (TMG) 6. Willing to attend for safety monitoring assessments 7. Willing to travel only to countries that can supply Eculizumab (to be confirmed with co-ordinating centre prior to travel). The following criteria must be met by those only wishing to be enrolled in the withdrawal component of the trial: 8. Able to perform or parent/guardian to perform and record self-monitoring urinalysis 9. Sexually active female patients must have a negative pregnancy test at screening and be using an effective contraception for the duration of the study (implant, injectable [combined hormone], intrauterine device, intrauterine system, male sterilisation, injectable (single hormone), combined oral, progesterone only) OR 10. Fulfil one of the following criteria: 10.1. Be postmenopausal 10.2. Have undergone surgical sterilisation |
| Participant exclusion criteria | 1. Severe non-renal disease manifestations at initial presentation with aHUS, which in the opinion of the Chief Investigator and/or the clinical members of the TMG makes the risk of treatment withdrawal unacceptable 2. Loss of a previous transplant kidney to recurrent aHUS 3. Transplant recipient with a pathogenic mutation in C3, CFH or CFB 4. Current or planned pregnancy 5. Unable to give informed consent or assent, or unable to obtain parent/guardian consent if under 16 years of age 6. Unable to comply with monitoring protocol 7. Current participation in another clinical trial 8. Haematuria rating of 3+ 9. Severe, uncontrolled hypertension (systolic blood pressure > 160 mmHg) that is likely to induce at TMA |
| Recruitment start date | 01/05/2018 |
| Recruitment end date | 30/11/2021 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centres
Freeman Road
NE7 7DN
United Kingdom
United Kingdom
United Kingdom
NW1 2PG
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
Sponsor information
Hospital/treatment centre
Freeman Hospital
Freeman Road
High Heaton
Newcastle-Upon-Tyne
NE7 7DN
England
United Kingdom
| Phone | +44 (0)191 2824454 |
|---|---|
| Tnu-tr.sponsormanagement@nhs.net | |
"ROR" |
https://ror.org/05p40t847 |
Funders
Funder type
Government
No information available
Results and Publications
| Intention to publish date | 31/03/2024 |
|---|---|
| Individual participant data (IPD) Intention to share | Yes |
| IPD sharing plan summary | Other |
| Publication and dissemination plan | Planned publication in a high-impact peer reviewed journal. |
| IPD sharing plan | The datasets generated and/or analysed during the current study during this study will be included in the subsequent results publication. |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Protocol article | 19/09/2022 | 20/09/2022 | Yes | No | |
| HRA research summary | 28/06/2023 | No | No |
Editorial Notes
13/12/2022: Contact details updated. Total final enrolment added.
20/09/2022: Publication reference added.
03/09/2021: The following changes were made to the trial record:
1. The recruitment end date was changed from 31/08/2021 to 30/11/2021.
2. The overall trial end date was changed from 31/08/2023 to 30/11/2023.
3. The intention to publish date was changed from 30/11/2023 to 31/03/2024.
02/06/2021: The following changes were made to the trial record:
1. The recruitment end date was changed from 31/05/2021 to 31/08/2021.
2. The overall trial end date was changed from 31/08/2022 to 31/08/2023.
3. The intention to publish date was changed from 31/12/2022 to 30/11/2023.
02/03/2021: The following changes were made to the trial record:
1. The recruitment end date was changed from 31/05/2020 to 31/05/2021.
2. The recruitment resumed.
21/04/2020: Due to current public health guidance, recruitment for this study has been paused.
24/10/2019: IPD sharing statement added.
09/09/2019: The following changes were made to the trial record:
1. The recruitment end date was changed from 31/08/2019 to 31/05/2020.
2. The overall trial end date was changed from 31/08/2021 to 31/08/2022.
3. The intention to publish date was changed from 31/12/2021 to 31/12/2022.
28/06/2019: The recruitment end date was changed from 31/05/2019 to 31/08/2019.
25/03/2019: The condition was updated from "Specialty: Renal disorders, Primary sub-specialty: Renal disorders; UKCRC code/ Disease: Renal and Urogenital/ Glomerular diseases" to "Atypical hemolytic uremic syndrome".
23/05/2018: Trial website address corrected.
