A randomised controlled trial to evaluate the effectiveness of a pharmacist's telephone reminders in reducing mortality in patients receiving polypharmacy

ISRCTN	ISRCTN48076318
DOI	https://doi.org/10.1186/ISRCTN48076318
Protocol serial number	HSRC/HCPF226103
Sponsor	Hong Kong Health Services Research Fund (Hong Kong)
Funder	Hong Kong SAR Government Health Services Research Committee (Hong Kong)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Prof Juliana CN Chan
Scientific

Dept of Medicine and Therapeutics
Chinese University of Hong Kong
The Prince of Wales Hospital
Shatin
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Hong Kong

Phone	+852 (0)2632 3138
Email	jchan@cuhk.edu.hk

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	To investigate the effects of compliance and periodic telephone counselling by a pharmacist on mortality in patients receiving polypharmacy.
Ethics approval(s)	Added as of 22/10/2007: Ethics approval received from the Chinese University of Hong Kong clinical research ethics committee.
Health condition(s) or problem(s) studied	Compliance to polypharmacy
Intervention	Patients randomised to the intervention group received a 10 - 15 minute telephone call from the pharmacist for education and counselling between clinic visits for 2 years. Patients in the control group did not receive any telephone reminders.
Intervention type	Other
Primary outcome measure(s)	Time from randomisation to death from any cause.
Key secondary outcome measure(s)	1. Changes in the rate of admission to hospital 2. Number of emergency room visits 3. Hospital stay in the two years before and after the screening visit 4. Changes in compliance
Completion date	01/06/1999

Participant type(s)	Patient
Age group	Adult
Sex	All
Target sample size at registration	502
Key inclusion criteria	Patients receiving polypharmacy defined as five or more chronic medications who were found to be non-compliant upon first assessment by pharmacist
Key exclusion criteria	1. Speak non-Cantonese dialects or a different language 2. Conditions that prevented effective communication (for example, patients who are deaf, mute, or have dementia or other psychological disorders) 3. Live in nursing homes with supervised treatment
Date of first enrolment	01/10/1998
Date of final enrolment	01/06/1999

Dept of Medicine and Therapeutics

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-
Hong Kong

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	Results	09/09/2006		Yes	No