Effects of the six-month training on cognitive, physical performance, and daily physical activity in older adults
| ISRCTN | ISRCTN70130279 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN70130279 |
| Protocol serial number | N/A |
| Sponsor | Swiss Federal Institute of Technology Zurich (ETH) (Switzerland) |
| Funders | Eidgenössische Technische Hochschule Zürich, Institute of Human Movement Sciences and Sport (Switzerland) |
- Submission date
- 17/05/2013
- Registration date
- 10/07/2013
- Last edited
- 10/07/2015
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Other
Plain English summary of protocol
Background and study aims
The objective of this study is to find out which combination of physical and cognitive (mental exercises) training is most effective to increase physical and cognitive (mental) performance in older adults from 70 years of age. Moreover, the study examines the effects of the training on individuals daily physical activity patterns, frequency of falls, and symptoms of depression.
Who can participate?
People over 70 years of age, able to walk at least 20 meters with or without walking aids and living independently or in a community residence.
What does the study involve?
90 participants are randomly allocated to one of the three different training programs. Two training programs combine physical and cognitive training, whereas the third program consists of physical exercise only and acts as a control group.
Intervention group one (video-game dancing)
Intervention group two (dual-task walking)
Intervention group three (control group, treadmill walking)
Subjects practice for six months, two times one hour per week. Testing of physical and cognitive performance takes place before the training program, after three months of training, and at the end of the program (six months). Participants will be tested again one year after completion of the training.
What are the possible benefits and risks of participating?
Participants possibly benefit from increased physical and cognitive fitness after completing the training program. The risk of falls is not greater than in normal life of the elderly participants. Special attention is given to minimize the risk of falls while training. No other risks or side effects are expected.
Where is the study run from?
The study is run by the Swiss Federal Institute of Technology (ETH) Zurich, Switzerland, Institute of Human Movement Sciences and Sport. Testing and training takes place at the Geriatrics Clinic St.Gallen, Switzerland.
When is the study starting and how long is it expected to run for?
The study started in September 2012 and will run until April 2014 (including one-year follow-up testing). The recruitment of participants completed in October 2012.
Who is funding the study?
Swiss Federal Institute of Technology (ETH), Zurich and Institute of Human Movement Sciences and Sport, Switzerland
Who is the main contact?
MSc Patrick Eggenberger, PhD Student, ETH Zurich, Switzerland, Institute of Human Movement Sciences and Sport
patrick.eggenberger@hest.ethz.ch
Contact information
Scientific
ETH Zurich
Institute of Human Movement Sciences and Sport
HIT J 32, Wolfgang-Pauli-Strasse 27
Zurich
CH-8093
Switzerland
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Single-centre three-groups pre-test, mid-test (three months), post-test (six-months) randomized controlled interventional trial with one-year follow-up testing |
| Secondary study design | Randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | Effects of the six-month multimodal training intervention on cognitive, physical performance, and daily physical activity in older adults |
| Study objectives | Study part A (cognition and gait): Combined physical and cognitive training (strength, balance, and virtual-reality video-game dancing) interventions can increase cognitive function (particularly attention) and gait parameters (particularly dual task cost of walking) to a greater extent than combined physical and cognitive training (strength, balance, and walking with memory tasks) and physical training alone (aerobic exercise, strength, and balance). Study part B (aerobic performance and executive function): Combined physical (aerobic exercise, strength, and balance) and cognitive training components, can increase measures of aerobic endurance performance [particularly heart rate variability (HRV) and heart rate recovery] to a greater extent than physical training (aerobic exercise, strength, and balance) alone. There is an association between HRV and executive function. Study part C (prevention of falls and one year follow up): Combined physical and cognitive training interventions, can decrease anxiety of falling and fall frequency to a greater extent than physical training (including aerobic exercise, strength, and balance) alone. One year after the six-month training intervention some selected physiological and cognitive measures are still elevated compared to pre-intervention level. |
| Ethics approval(s) | Canton of St.Gallen Ethics Committee (Switzerland), 03/09/2012, ref: EKSG 12/092 |
| Health condition(s) or problem(s) studied | Geriatrics related conditions of independent living and community dwelling in old adults |
| Intervention | Participants follow a six months guided training intervention. Training sessions take place twice weekly for one hour each session. Subjects are randomized into three groups with different training programs. The participants of all three training groups will practice a basic training program consisting of strength and balance exercises. Strength exercises are performed using own body weight, small barbells, weight-wests, and resistive rubber-bands. The intensity of these exercises is increased progressively and performed with high movement velocity (power training). Participants are accustomed slowly to the exercises and are continuously monitored by the instructors. 1. Intervention group one (video-game dancing): This group executes virtual-reality video-game dance training in addition to the strength and balance exercises. For the dance training, participants follow the step instructions (arrows) presented on a computer screen. Movements have to be carried out with the rhythm of the music. Participants are standing on a pressure-sensitive platform, which records right and false movements. For security reasons, participants hold on to ropes that are attached to the ceiling. 2. Intervention group two (dual-task walking): This group also performs strength and balance exercises as a basic training program. Additionally, this group executes dual-task training with walking on a treadmill while doing memory exercises presented on a computer screen. 3. Intervention group three (control group, treadmill walking): This group acts as a control group and does treadmill walking without any cognitive tasks, in addition to the basic strength and balance training. |
| Intervention type | Behavioural |
| Primary outcome measure(s) |
1. Study part A (cognition and gait): |
| Key secondary outcome measure(s) |
1. Study part A (cognition and gait): |
| Completion date | 30/04/2014 |
Eligibility
| Participant type(s) | Healthy volunteer |
|---|---|
| Age group | Senior |
| Sex | All |
| Target sample size at registration | 90 |
| Key inclusion criteria | 1. Age over 70 years 2. Signed informed consent statement 3. Ability to walk at least 20 meters with or without walking aids 4. Independent living or community dwelling |
| Key exclusion criteria | 1. Severe cognitive impairment (Mini-Mental State Examination below 22 points) 2. Rapidly progressive or terminal illness, acute illness or unstable chronic illness 3. Alzheimer disease, dementia, or recent head injury |
| Date of first enrolment | 03/09/2012 |
| Date of final enrolment | 01/10/2012 |
Locations
Countries of recruitment
- Switzerland
Study participating centre
CH-8093
Switzerland
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |