Medical Research Council trial of treatment of mild hypertension
| ISRCTN | ISRCTN72268178 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN72268178 |
| Protocol serial number | N/A |
| Sponsor | Sponsor not defined - Record provided by the Medical Research Council (UK) |
| Funder | Medical Research Council (UK) |
- Submission date
- 07/09/2005
- Registration date
- 08/09/2005
- Last edited
- 19/05/2011
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Tom Meade
Scientific
Scientific
Non-communicable Disease Epidemiology Unit
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
| tom.meade@lshtm.ac.uk |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | Lowering mild to moderate hypertension leads to a reduction in rates of stroke, deaths due to hypertension and of coronary events in men and women aged 35-64 years. |
| Ethics approval(s) | Not provided at time of registration. |
| Health condition(s) or problem(s) studied | Hypertension |
| Intervention | Bendrofluazide or propranolol compared with placebo. |
| Intervention type | Drug |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Bendrofluazide and propranolol |
| Primary outcome measure(s) |
Stroke, deaths due to hypertension and of coronary events. |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 01/12/1982 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 18000 |
| Key inclusion criteria | Men and women age 35-64 at recruitment in 176 general practices in the Medical Research Council's General Practice Research Framework. Diastolic blood pressure of 90-109 mmHg with a systolic pressure below 200 mmHg. |
| Key exclusion criteria | Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease, pregnancy. |
| Date of first enrolment | 01/01/1973 |
| Date of final enrolment | 01/12/1982 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
Non-communicable Disease Epidemiology Unit
London
WC1E 7HT
United Kingdom
WC1E 7HT
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 15/02/1992 | Yes | No |
