Stroke at younger ages
| ISRCTN | ISRCTN83802006 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN83802006 |
| IRAS number | 328197 |
| Secondary identifying numbers | IRAS 328197 |
- Submission date
- 22/01/2024
- Registration date
- 01/02/2024
- Last edited
- 06/06/2025
- Recruitment status
- Not yet recruiting
- Overall study status
- Ongoing
- Condition category
- Cancer
Plain English summary of protocol
Background and study aims
We have seen a doubling in the number of new stroke cases in adults under the age of 55 years in the last 10 years in the UK and in other high-income countries. However, the reasons for this increase remain unclear. The aim of this study is to find out how traditional stroke risk factors that are more common at older ages, such as high blood pressure, diabetes, high cholesterol level, smoking and obesity, might contribute to the occurrence of stroke at younger ages. The researchers are also hoping to find out if emerging stroke risk factors also play a role in the rising number of young stroke cases, such as long working hours, stress and mental health conditions.
Who can participate?
Adult patients aged between 18-54 years with diagnosed stroke
What does the study involve?
The study will involve a short questionnaire (about 30 minutes) through an interview with the local study team, where they will collect information on participants' past medical history, lifestyle-related factors, family history, birth history, and other stroke risk factors. The research team will also collect relevant information about the stroke episode. The interview can be done face-to-face during the hospital stay or by phone after participants are discharged. All patients will undergo centralised administrative follow-up via record linkage for up to 30 years.
What are the possible benefits and risks of participating?
The study only includes a short questionnaire and there are no unlikely foreseeable risks associated.
Where is the study run from?
Oxford University (UK)
When is the study starting and how long is it expected to run for?
October 2023 to December 2056
Who is funding the study?
1. Oxford University (UK)
2. Oxford BRC (UK)
3. Wellcome Trust (UK)
Who is the main contact?
Dr Linxin Li, linxin.li@ndcn.ox.ac.uk
Contact information
Public, Scientific, Principal Investigator
Wolfson Centre for Prevention of Stroke and Dementia
Wolfson Building
John Radcliffe Hospital
Oxford
OX3 9DU
United Kingdom
 ORCID ID |
0000-0002-3636-8355 |
|---|---|
| Phone | +44 (0)1865 611277 |
| linxin.li@ndcn.ox.ac.uk |
Study information
| Study design | Prospective cohort study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Case-control study |
| Study setting(s) | Hospital |
| Study type | Prevention, Quality of life |
| Participant information sheet | Not available in web format, please use contact details to request a participant information sheet |
| Scientific title | National Young Stroke Study |
| Study acronym | NYSS |
| Study objectives | The primary objectives of this study are to provide up-to-date and reliable estimates of the associations of traditional modifiable risk factors and emerging risk factors and young stroke. |
| Ethics approval(s) |
Approved 22/01/2024, North West - Greater Manchester South Research Ethics Committee (3rd Floor, Barlow House, 4 Minshull Street, Manchester, M1 3DZ, United Kingdom; +44 (0)207 104 8278; gmsouth.rec@hra.nhs.uk), ref: 24/NW/0003 |
| Health condition(s) or problem(s) studied | Stroke |
| Intervention | The study will involve a short questionnaire (about 30 minutes) through an interview with the local study team, where they will collect information on participants' past medical history, lifestyle-related factors, family history, birth history, and other stroke risk factors. The research team will also collect relevant information about the stroke episode. The interview can be done face-to-face during the hospital stay or by phone after participants are discharged. All patients will undergo centralised administrative follow-up via record linkage for up to 30 years. |
| Intervention type | Other |
| Primary outcome measure | 1. Traditional vascular risk factors (e.g. hypertension, diabetes, hyperlipidaemia, obesity, smoking, alcohol excess) measured using questionnaire/medical records at baseline 2. Emerging risk factors (e.g. depression, anxiety and other mental health conditions, long working hours, stress, autoimmune conditions, oral health) measured using questionnaire/medical records at baseline |
| Secondary outcome measures | 1. Long-term vascular (recurrent stroke, myocardial infarction, dementia and vascular death) and non-vascular outcomes (cancer and mental health conditions) measured using medical record linkage at 5, 10, 20 and 30 years 2. Stroke severity measured using National Institutes of Health Stroke Scale (NIHSS) at baseline 3. Disability measured using modified Rankin scale at baseline in the first instance 4. Quality of life measured using EQ-5D at baseline in the first instance |
| Overall study start date | 01/10/2023 |
| Completion date | 31/12/2056 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Upper age limit | 54 Years |
| Sex | Both |
| Target number of participants | 2000 |
| Key inclusion criteria | 1. Patient is willing and able to give informed consent for participation in the study, or favourable consultee advice for adults lacking capacity OR If consent or consultee advice was not feasible, CAG/Section 251 support for data collection 2. Male or Female, aged 18 to 54 years 3. A diagnosis of ischaemic stroke (including retinal artery occlusion) OR A diagnosis of intracerebral haemorrhage |
| Key exclusion criteria | 1. Intracerebral haemorrhage as a result of trauma 2. Ischaemic stroke or intracerebral haemorrhage as a result of cerebral venous thrombosis |
| Date of first enrolment | 01/10/2025 |
| Date of final enrolment | 31/12/2026 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centres
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
United Kingdom
John Radcliffe Hospital
Oxford
OX3 9DU
United Kingdom
Sponsor information
University/education
Research Governance, Ethics and Assurance
Boundary Brook House
Churchill Drive
Oxford
OX3 7GB
England
United Kingdom
| Phone | +44 (0)1865-289885 |
|---|---|
| RGEA.Sponsor@admin.ox.ac.uk | |
| Website | http://www.ox.ac.uk/ |
"ROR" |
https://ror.org/052gg0110 |
Funders
Funder type
University/education
Private sector organisation / Universities (academic only)
- Alternative name(s)
- St Cross College, University of Oxford
- Location
- United Kingdom
Private sector organisation / Research institutes and centers
- Alternative name(s)
- NIHR Biomedical Research Centre, Oxford, OxBRC
- Location
- United Kingdom
Private sector organisation / Trusts, charities, foundations (both public and private)
- Alternative name(s)
- Wellcome, WT
- Location
- United Kingdom
Results and Publications
| Intention to publish date | 31/12/2029 |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Data sharing statement to be made available at a later date |
| Publication and dissemination plan | Planned publication in a high-impact peer-reviewed journal. |
| IPD sharing plan | The data-sharing plans for the current study are currently under development and will be made available at a later date. |
Editorial Notes
06/06/2025: The recruitment start date was changed from 01/06/2025 to 01/10/2025.
21/01/2025: The recruitment start date was changed from 01/01/2025 to 01/06/2025.
08/10/2024: The recruitment start date was changed from 01/10/2024 to 01/01/2025.
09/09/2024: The recruitment start date was changed from 01/09/2024 to 01/10/2024.
30/05/2024: The recruitment start date was changed from 01/04/2024 to 01/09/2024.
22/01/2024: Study's existence confirmed by the North West - Greater Manchester South Research Ethics Committee.
