Multicentre study of early Epilepsy and Single Seizures
| ISRCTN | ISRCTN98767960 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN98767960 |
| Secondary identifying numbers | G9125371 |
- Submission date
- 23/10/2000
- Registration date
- 23/10/2000
- Last edited
- 23/07/2012
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nervous System Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English Summary
Not provided at time of registration
Contact information
Prof David Chadwick
Scientific
Scientific
Department of Neurological Science
The Walton Centre
Lower Lane
Fazakerley
Liverpool
L9 7LJ
United Kingdom
| Phone | +44 (0)151 529 5461 |
|---|---|
| dwc@liv.ac.uk |
Study information
| Study design | Multicentre randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Treatment |
| Scientific title | |
| Study acronym | MESS |
| Study hypothesis | 1. To compare seizure recurrence rates associated with policies of immediate or delayed antiepileptic drug therapy in patients with single seizures and early epilepsy using a pragmatic randomized parallel group design. 2. To identify factors of prognostic importance in the recurrence of seizures in the early course of epilepsy 3. To examine the psychosocial outcome of the two randomized policies |
| Ethics approval(s) | Not provided at time of registration |
| Condition | Epilepsy |
| Intervention | Immediate/delayed antiepileptic drug therapy |
| Intervention type | Other |
| Primary outcome measure | Time to first seizure, time to remission, patient perceived quality of life |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/01/1993 |
| Overall study end date | 31/12/2002 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 1800 |
| Participant inclusion criteria | 1. An adequately documented recent history of one or more clinically definite spontaneous unprovoked epileptic seizures 2. Clinician is uncertain whether to treat or not |
| Participant exclusion criteria | Not provided at time of registration |
| Recruitment start date | 01/01/1993 |
| Recruitment end date | 31/12/2002 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Department of Neurological Science
Liverpool
L9 7LJ
United Kingdom
L9 7LJ
United Kingdom
Sponsor information
Medical Research Council (MRC) (UK)
Research council
Research council
20 Park Crescent
London
W1B 1AL
United Kingdom
| Phone | +44 (0)20 7636 5422 |
|---|---|
| clinical.trial@headoffice.mrc.ac.uk | |
| Website | http://www.mrc.ac.uk |
Funders
Funder type
Research council
Medical Research Council
Government organisation / National government
Government organisation / National government
- Alternative name(s)
- Medical Research Council (United Kingdom), UK Medical Research Council, MRC
- Location
- United Kingdom
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/06/2005 | Yes | No | |
| Results article | results | 01/04/2006 | Yes | No | |
| Results article | results | 28/11/2006 | Yes | No | |
| Results article | results | 07/12/2010 | Yes | No | |
| Results article | results | 01/08/2012 | Yes | No |
