Comparative efficacy of albendazole and mebendazole against hookworm infection in Laos
| ISRCTN | ISRCTN29126001 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN29126001 |
| Secondary identifying numbers | N/A |
- Submission date
- 25/04/2008
- Registration date
- 09/10/2008
- Last edited
- 02/05/2012
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Peter Odermatt
Scientific
Scientific
Swiss Tropical Institute
Department of Public Health and Epidemiology
Socinstrasse 57
Basel
4002
Switzerland
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Treatment |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | Comparative efficacy of Albendazole and Mebendazole against hookworm infection: Randomised, controlled trial in schoolchildren in Khamkeuth district, Bolikhamxay province, Laos |
| Study acronym | AlMebLaos |
| Study objectives | Albendazole (400 mg single dose) is more effective than mebendazole (500 mg single dose) in clearing hookworm infection. |
| Ethics approval(s) | National Ethics Committee for Health Research, Vientiane, Laos. Date of approval: 01/04/2008 (ref: 170 /NECHR) |
| Health condition(s) or problem(s) studied | Hookworm infection, and other intestinal helminth infections |
| Intervention | Mebendazole (500 mg, single dose, oral) vs albendzole (400 mg, single dose, oral) treatment. |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Albendazole and mebendazole |
| Primary outcome measure | Hookworm parasite clearance (no hookworm egg in four Kato-Katz slides taken on two stool samples) at 21-23 days after treatment |
| Secondary outcome measures | Reduction of intensity of infection (reduction of mean number of hookworm eggs counted on four Kato-Katz slides taken on two different stool samples) at 21-23 days after treatment |
| Overall study start date | 28/04/2008 |
| Completion date | 30/05/2008 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Child |
| Lower age limit | 6 Years |
| Upper age limit | 16 Years |
| Sex | Both |
| Target number of participants | 190 |
| Key inclusion criteria | 1. School-child age between 6 and 16 years, both male and female 2. Hookworm infected (at least one of four egg-positive Kato-Katz slide, established on 2 stool samples) |
| Key exclusion criteria | 1. Pregnancy 2. Severe illness 3. Non-consent |
| Date of first enrolment | 28/04/2008 |
| Date of final enrolment | 30/05/2008 |
Locations
Countries of recruitment
- Lao People's Democratic Republic
- Switzerland
Study participating centre
Swiss Tropical Institute
Basel
4002
Switzerland
4002
Switzerland
Sponsor information
Swiss National Science Foundation (Switzerland)
Government
Government
Wildhainweg 3
P.O. Box 8232
Bern
3001
Switzerland
| Website | http://www.snf.ch |
|---|---|
"ROR" |
https://ror.org/00yjd3n13 |
Funders
Funder type
Government
Swiss National Science Foundation (Switzerland)
Private sector organisation / Trusts, charities, foundations (both public and private)
Private sector organisation / Trusts, charities, foundations (both public and private)
- Alternative name(s)
- Schweizerischer Nationalfonds, Swiss National Science Foundation, Fonds National Suisse de la Recherche Scientifique, Fondo Nazionale Svizzero per la Ricerca Scientifica, Fonds National Suisse, Fondo Nazionale Svizzero, Schweizerische Nationalfonds, SNF, SNSF, FNS
- Location
- Switzerland
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/01/2012 | Yes | No |
